Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial

To explore the efficacy of Chinese herbal formula compared with donepezil 5 mg/day in patients with mild Alzheimer's disease (AD). Patients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride (DH) group d...

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Published in:PloS one 2015-06, Vol.10 (6), p.e0130353-e0130353
Main Authors: Zhang, Yulian, Lin, Cuiru, Zhang, Linlin, Cui, Yuanwu, Gu, Yun, Guo, Jiakui, Wu, Di, Li, Qiang, Song, Wanshan
Format: Article
Language:English
Subjects:
Acupuncture
Aged
Aged, 80 and over
Aluminum
Alzheimer Disease - drug therapy
Alzheimer's disease
Alzheimers disease
Amyloid beta-Peptides - metabolism
Anti-Alzheimer's disease agents
China
Chinese medicine
Clinical trials
Cog
Cognition - drug effects
Cognitive ability
Comparative analysis
Dementia
Disease control
Donepezil
Double-Blind Method
Drug dosages
Drugs, Chinese Herbal - therapeutic use
Female
Geriatrics
Herbal medicine
Hospitals
Humans
Hypotheses
Indans - therapeutic use
Ligusticum
Male
Medical treatment
Memory
Mental Status Schedule
Middle Aged
Molecular weight
Patients
Piperidines - therapeutic use
Randomization
Rodents
Statistical analysis
Treatment Outcome
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cited_by cdi_FETCH-LOGICAL-c692t-b97151e1f1e9aa29220ff937f923327e31245a64a1286af36c6b397ac8833a853
cites cdi_FETCH-LOGICAL-c692t-b97151e1f1e9aa29220ff937f923327e31245a64a1286af36c6b397ac8833a853
container_end_page e0130353
container_issue 6
container_start_page e0130353
container_title PloS one
container_volume 10
creator Zhang, Yulian
Lin, Cuiru
Zhang, Linlin
Cui, Yuanwu
Gu, Yun
Guo, Jiakui
Wu, Di
Li, Qiang
Song, Wanshan
description To explore the efficacy of Chinese herbal formula compared with donepezil 5 mg/day in patients with mild Alzheimer's disease (AD). Patients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride (DH) group during the 24-week trial. The outcomes were measured by ADAS-cog, MMSE, ADL, and NPI with linear mixed-effect models. 144 patients were randomized. The mean scores of ADAS-cog and MMSE in both YHD group and DH group both improved at the end of the 24-week treatment period. The results also revealed that YHD was better at improving the mean scores of ADAS-cog and MMSE than DH. Linear mixed-effect models with repeated measures showed statistical significance in time × group interaction effect of ADAS-cog and also in time × group interaction effect of MMSE. The data showed YHD was superior to DH in improving the scores and long term efficacy. Our study suggests that Chinese herbal formula YHD is beneficial and effective for cognitive improvement in patients with mild AD and the mechanism might be through reducing amyloid-β (Aβ) plaque deposition in the hippocampus. Chinese Clinical Trial Registry ChiCTR-TRC-12002846.
doi_str_mv 10.1371/journal.pone.0130353
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subjects Acupuncture
Aged
Aged, 80 and over
Aluminum
Alzheimer Disease - drug therapy
Alzheimer's disease
Alzheimers disease
Amyloid beta-Peptides - metabolism
Anti-Alzheimer's disease agents
China
Chinese medicine
Clinical trials
Cog
Cognition - drug effects
Cognitive ability
Comparative analysis
Dementia
Disease control
Donepezil
Double-Blind Method
Drug dosages
Drugs, Chinese Herbal - therapeutic use
Female
Geriatrics
Herbal medicine
Hospitals
Humans
Hypotheses
Indans - therapeutic use
Ligusticum
Male
Medical treatment
Memory
Mental Status Schedule
Middle Aged
Molecular weight
Patients
Piperidines - therapeutic use
Randomization
Rodents
Statistical analysis
Treatment Outcome
title Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial
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