Impact of Obstructive Sleep Apnea on Liver Fat Accumulation According to Sex and Visceral Obesity

Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortali...

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Bibliographic Details
Published in:PloS one 2015-06, Vol.10 (6), p.e0129513-e0129513
Main Authors: Toyama, Yoshiro, Tanizawa, Kiminobu, Kubo, Takeshi, Chihara, Yuichi, Harada, Yuka, Murase, Kimihiko, Azuma, Masanori, Hamada, Satoshi, Hitomi, Takefumi, Handa, Tomohiro, Oga, Toru, Chiba, Tsutomu, Mishima, Michiaki, Chin, Kazuo
Format: Article
Language:English
Subjects:
Accumulation
Adipose tissue
Adult
Alanine
Alanine transaminase
Alcohol use
Apnea
Body mass
Body mass index
Body size
Computation
Computed tomography
Female
Females
Gender aspects
Gender differences
Health aspects
Humans
Insulin
Insulin resistance
Intra-Abdominal Fat - pathology
Liver
Liver - pathology
Liver diseases
Male
Males
Multivariate Analysis
Obesity
Oxygen
Oxygen content
Patients
Polysomnography
Regression Analysis
Retrospective Studies
Saturation
Sex
Sex differences
Sex Factors
Sleep
Sleep apnea
Sleep Apnea, Obstructive - pathology
Sleep disorders
Studies
Tomography, X-Ray Computed
Triglycerides
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Summary:Associations between obstructive sleep apnea (OSA) and liver fat accumulation have been frequently investigated because both morbidities are common. Visceral fat was reported to be closely related to OSA and liver fat accumulation. Recently, sex differences in the association between OSA and mortality have gained much attention. To investigate the associations among OSA, liver fat accumulation as determined by computed tomography, and visceral fat area and their sex differences. Studied were 188 males and 62 females who consecutively underwent polysomnography and computed tomography. Although the apnea-hypopnea index was positively correlated with liver fat accumulation in the total males, none of the OSA-related factors was independently associated with liver fat accumulation in either the total male or female participants in the multivariate analyses. When performing subanalyses using a specific definition for Japanese of obesity or visceral obesity (body mass index (BMI) ≥25 kg/m2 or visceral fat area ≥100 cm2), in only males without visceral obesity, percent sleep time with oxygen saturation
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0129513