Similar Occurrence of Febrile Episodes Reported in Non-Atopic Children at Three to Five Years of Age after Prebiotics Supplemented Infant Formula

This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic...

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Bibliographic Details
Published in:PloS one 2015-06, Vol.10 (6), p.e0129927-e0129927
Main Authors: van Stuijvenberg, Margriet, Stam, José, Grüber, Christoph, Mosca, Fabio, Arslanoglu, Sertac, Chirico, Gaetano, Braegger, Christian P, Riedler, Josef, Boehm, Günther, Sauer, Pieter J J
Format: Article
Language:English
Subjects:
Antibiotics
Atopy
Breast feeding
Breastfeeding & lactation
Chains
Child, Preschool
Children
Dietary Supplements - adverse effects
Double-Blind Method
Europe - epidemiology
Female
Fever - epidemiology
Fever - etiology
Follow-Up Studies
Humans
Incidence
Infant Formula - administration & dosage
Infant, Newborn
Infants
Male
Oligosaccharides
Parents
Pectin
Population studies
Prebiotics
Prebiotics - adverse effects
Prospective Studies
Randomization
Risk Factors
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Summary:This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130). In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0129927