Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells

This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) accompanying IgG4-positive cells. Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-pos...

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Published in:PloS one 2015-06, Vol.10 (6), p.e0131458-e0131458
Main Authors: Lee, Min Joung, Kim, Namju, Choe, Ji-Young, Khwarg, Sang In, Jeon, Yoon Kyung, Choung, Ho-Kyung, Kim, Ji Eun
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens
B-cell lymphoma
Biopsy
Cancer
Chlamydia
Chlamydia psittaci
Demographics
Deoxyribonucleic acid
Diagnosis
DNA
Eye Neoplasms - immunology
Eye Neoplasms - metabolism
Eye Neoplasms - pathology
Female
Fibrosis
Hospitals
Humans
Immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - metabolism
Immunohistochemistry
Infiltration
Lacrimal gland and Nasolacrimal duct
Life assessment
Lymphocytes B
Lymphoma
Lymphoma, B-Cell, Marginal Zone - immunology
Lymphoma, B-Cell, Marginal Zone - metabolism
Lymphoma, B-Cell, Marginal Zone - pathology
Lymphomas
Male
Middle Aged
Pathology
Patients
Plasma Cells - metabolism
Plasma Cells - pathology
Prognosis
Studies
Young Adult
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cited_by cdi_FETCH-LOGICAL-c692t-35497278899d0a3bc2e14ef04bbc02d878921a1df5cf690cd7fb67f24d1fbc023
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container_title PloS one
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creator Lee, Min Joung
Kim, Namju
Choe, Ji-Young
Khwarg, Sang In
Jeon, Yoon Kyung
Choung, Ho-Kyung
Kim, Ji Eun
description This study aims to analyze clinical and pathological characteristics of ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL) accompanying IgG4-positive cells. Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-positive cells and the ratio of IgG/IgG4 were evaluated by immunohistochemistry in the biopsy specimens. The patients were divided into two groups based on the absolute number and the ratio of IgG4-positive cells (IgG4-posivite vs IgG4-negative groups). The demographic data, clinical staging at diagnosis, histopathological characteristics, and response to initial treatment were comparatively analyzed between the 2 groups. Five (10%) of 50 patients were defined as IgG4-positive group, and all the cases showed characteristic histological features such as extensive plasma cell infiltration and dense fibrosis. Most of these patients (4 of 5 patients) had lymphoma of the lacrimal gland. The patients from the IgG4-positive group showed a lower response rate to initial treatment (87.5 vs 33%, p = 0.03) than IgG4-negative group with a median follow-up period of 38 months. A part of the ocular adnexal EMZLs were accompanied with IgG4-positive cells. Significantly, most IgG4-positive ocular adnexal EMZLs occurred in the lacrimal gland, and can be related with a more frequent treatment failure.
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Fifty patients with a diagnosis of primary non-conjunctival ocular adnexal EMZL were enrolled in this study. The number of IgG4-positive cells and the ratio of IgG/IgG4 were evaluated by immunohistochemistry in the biopsy specimens. The patients were divided into two groups based on the absolute number and the ratio of IgG4-positive cells (IgG4-posivite vs IgG4-negative groups). The demographic data, clinical staging at diagnosis, histopathological characteristics, and response to initial treatment were comparatively analyzed between the 2 groups. Five (10%) of 50 patients were defined as IgG4-positive group, and all the cases showed characteristic histological features such as extensive plasma cell infiltration and dense fibrosis. Most of these patients (4 of 5 patients) had lymphoma of the lacrimal gland. The patients from the IgG4-positive group showed a lower response rate to initial treatment (87.5 vs 33%, p = 0.03) than IgG4-negative group with a median follow-up period of 38 months. A part of the ocular adnexal EMZLs were accompanied with IgG4-positive cells. Significantly, most IgG4-positive ocular adnexal EMZLs occurred in the lacrimal gland, and can be related with a more frequent treatment failure.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26111022</pmid><doi>10.1371/journal.pone.0131458</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
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1932-6203
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source Publicly Available Content Database; PubMed Central
subjects Adult
Aged
Antigens
B-cell lymphoma
Biopsy
Cancer
Chlamydia
Chlamydia psittaci
Demographics
Deoxyribonucleic acid
Diagnosis
DNA
Eye Neoplasms - immunology
Eye Neoplasms - metabolism
Eye Neoplasms - pathology
Female
Fibrosis
Hospitals
Humans
Immunoglobulin G
Immunoglobulin G - analysis
Immunoglobulin G - metabolism
Immunohistochemistry
Infiltration
Lacrimal gland and Nasolacrimal duct
Life assessment
Lymphocytes B
Lymphoma
Lymphoma, B-Cell, Marginal Zone - immunology
Lymphoma, B-Cell, Marginal Zone - metabolism
Lymphoma, B-Cell, Marginal Zone - pathology
Lymphomas
Male
Middle Aged
Pathology
Patients
Plasma Cells - metabolism
Plasma Cells - pathology
Prognosis
Studies
Young Adult
title Clinicopathological Analysis of Ocular Adnexal Extranodal Marginal Zone B-Cell Lymphoma with IgG4-Positive Cells
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