The UL13 and US3 Protein Kinases of Herpes Simplex Virus 1 Cooperate to Promote the Assembly and Release of Mature, Infectious Virions

Herpes simplex virus type 1 (HSV-1) encodes two bona fide serine/threonine protein kinases, the US3 and UL13 gene products. HSV-1 ΔUS3 mutants replicate with wild-type efficiency in cultured cells, and HSV-1 ΔUL13 mutants exhibit

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Bibliographic Details
Published in:PloS one 2015-06, Vol.10 (6), p.e0131420-e0131420
Main Authors: Gershburg, Svetlana, Geltz, Joshua, Peterson, Karin E, Halford, William P, Gershburg, Edward
Format: Article
Language:English
Subjects:
Accumulation
Animals
Assembly
Biology
Cassettes
Cells, Cultured
Cercopithecus aethiops
Cyclin-dependent kinases
Cytomegalovirus
Deoxyribonucleic acid
DNA
DNA biosynthesis
DNA replication
Fluorescence
Gene expression
Genes
Glycoproteins
Green fluorescent protein
Health aspects
Herpes simplex
Herpes Simplex - genetics
Herpes Simplex - pathology
Herpes Simplex - virology
Herpes simplex virus
Herpes viruses
Humans
Immunology
Infectious diseases
Kinases
Localization
Medicine
Mutant Proteins - genetics
Mutant Proteins - physiology
Mutants
Protein kinase
Protein kinases
Protein Kinases - genetics
Protein Kinases - physiology
Protein-Serine-Threonine Kinases - genetics
Protein-Serine-Threonine Kinases - physiology
Proteins
Reduction
Replication
RNA polymerase
Serine
Steady state
Threonine
Vero Cells
Viral Proteins - genetics
Viral Proteins - physiology
Virions
Virus Assembly - genetics
Virus replication
Virus Shedding - genetics
Viruses
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Description
Summary:Herpes simplex virus type 1 (HSV-1) encodes two bona fide serine/threonine protein kinases, the US3 and UL13 gene products. HSV-1 ΔUS3 mutants replicate with wild-type efficiency in cultured cells, and HSV-1 ΔUL13 mutants exhibit
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0131420