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New Metrics for Evaluating Viral Respiratory Pathogenesis

Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary f...

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Bibliographic Details
Published in:PloS one 2015-06, Vol.10 (6), p.e0131451-e0131451
Main Authors: Menachery, Vineet D, Gralinski, Lisa E, Baric, Ralph S, Ferris, Martin T
Format: Article
Language:English
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Summary:Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography was used to directly measure changes in pulmonary function during two respiratory viral infections. This methodology closely tracked with traditional pathogenesis metrics, distinguished both virus- and dose-specific responses, and identified long-term respiratory changes following both SARS-CoV and Influenza A Virus infection. Together, the work highlights the utility of examining respiratory function following infection in order to fully understand viral pathogenesis.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0131451