Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence

Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-06, Vol.10 (6), p.e0131017-e0131017
Main Authors: Yen, Che-Hung, Yeh, Yi-Wei, Liang, Chih-Sung, Ho, Pei-Shen, Kuo, Shin-Chang, Huang, Chang-Chih, Chen, Chun-Yen, Shih, Mei-Chen, Ma, Kuo-Hsing, Peng, Giia-Sheun, Lu, Ru-Band, Huang, San-Yuan
Format: Article
Language:English
Subjects:
Age
Alcoholism
Alcoholism - metabolism
Alcohols
Amphetamines
Availability
Brain
Brain research
Case-Control Studies
Cognition
Cognition & reasoning
Cognition Disorders - metabolism
Cognitive ability
Demography
Dopamine
Dopamine Plasma Membrane Transport Proteins - metabolism
Dopamine transporter
Drug dependence
Geriatrics
Human subjects
Humans
Male
Medical imaging
Memory
Mental disorders
Neuroimaging
Neurosciences
Organotechnetium Compounds - metabolism
Patients
Personality
Personality traits
Phenols (Class of compounds)
Psychiatry
Schizophrenia
Smoking
Statistics, Nonparametric
Studies
Subgroups
Tomography
Tropanes - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453
cites cdi_FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453
container_end_page e0131017
container_issue 6
container_start_page e0131017
container_title PloS one
container_volume 10
creator Yen, Che-Hung
Yeh, Yi-Wei
Liang, Chih-Sung
Ho, Pei-Shen
Kuo, Shin-Chang
Huang, Chang-Chih
Chen, Chun-Yen
Shih, Mei-Chen
Ma, Kuo-Hsing
Peng, Giia-Sheun
Lu, Ru-Band
Huang, San-Yuan
description Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p < 0.001), as well as diminished performance on the WCST (p < 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.
doi_str_mv 10.1371/journal.pone.0131017
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1692019952</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A419881384</galeid><doaj_id>oai_doaj_org_article_85f5cb21f7674bcda8fa122557de7aec</doaj_id><sourcerecordid>A419881384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453</originalsourceid><addsrcrecordid>eNqNk01vEzEQhlcIREvhHyBYCQnBIcHeD699qRS1fFQqFJXC1ZrYs4kjxw62N9B_j0PSqkE9IB9sjZ95x37tKYrnlIxp3dF3Cz8EB3a88g7HhNaU0O5BcUhFXY1YReqHd9YHxZMYF4S0NWfscXFQMVoR3nSHhbtEPSjU5alfwdI4LK8CuLjyIWEoJ2swFqbGmnRdgtPlFxyCV37mTDJrLE-xN8qkWBpXfgaL5VdIBl0O_DJpXk6s8nNvM7ZCp9EpfFo86sFGfLabj4rvH95fnXwanV98PDuZnI8UE1Ua1Zy3U6h5zRAoMtYwQRRgRYBVumdUE00F1rxvGEx7IEwxLURDVUWEgKatj4qXW92V9VHurIqSZnVChWirTJxtCe1hIVfBLCFcSw9G_g34MJMQklEWJW_7Vk0r2nesa6ZKA--BVlXbdho7QJW1jnfVhukStcoOBLB7ovs7zszlzK9l0_BOiC4LvNkJBP9zwJjk0kSF1oJDP2zP3bW0ETyjr_5B77_djprlV5HG9T7XVRtROWmo4JzWvMnU-B4qD41Lo_K_6k2O7yW83UvITMLfaQZDjPLs2-X_sxc_9tnXd9g5gk3z6O2QjHdxH2y2oAo-xoD9rcmUyE1b3LghN20hd22R017cfaDbpJs-qP8AdgEIww</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1692019952</pqid></control><display><type>article</type><title>Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence</title><source>Publicly Available Content (ProQuest)</source><source>PubMed Central</source><creator>Yen, Che-Hung ; Yeh, Yi-Wei ; Liang, Chih-Sung ; Ho, Pei-Shen ; Kuo, Shin-Chang ; Huang, Chang-Chih ; Chen, Chun-Yen ; Shih, Mei-Chen ; Ma, Kuo-Hsing ; Peng, Giia-Sheun ; Lu, Ru-Band ; Huang, San-Yuan</creator><contributor>Hashimoto, Kenji</contributor><creatorcontrib>Yen, Che-Hung ; Yeh, Yi-Wei ; Liang, Chih-Sung ; Ho, Pei-Shen ; Kuo, Shin-Chang ; Huang, Chang-Chih ; Chen, Chun-Yen ; Shih, Mei-Chen ; Ma, Kuo-Hsing ; Peng, Giia-Sheun ; Lu, Ru-Band ; Huang, San-Yuan ; Hashimoto, Kenji</creatorcontrib><description>Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p &lt; 0.001), as well as diminished performance on the WCST (p &lt; 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0131017</identifier><identifier>PMID: 26120847</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Alcoholism ; Alcoholism - metabolism ; Alcohols ; Amphetamines ; Availability ; Brain ; Brain research ; Case-Control Studies ; Cognition ; Cognition &amp; reasoning ; Cognition Disorders - metabolism ; Cognitive ability ; Demography ; Dopamine ; Dopamine Plasma Membrane Transport Proteins - metabolism ; Dopamine transporter ; Drug dependence ; Geriatrics ; Human subjects ; Humans ; Male ; Medical imaging ; Memory ; Mental disorders ; Neuroimaging ; Neurosciences ; Organotechnetium Compounds - metabolism ; Patients ; Personality ; Personality traits ; Phenols (Class of compounds) ; Psychiatry ; Schizophrenia ; Smoking ; Statistics, Nonparametric ; Studies ; Subgroups ; Tomography ; Tropanes - metabolism</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0131017-e0131017</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Yen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Yen et al 2015 Yen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453</citedby><cites>FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1692019952/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1692019952?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26120847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hashimoto, Kenji</contributor><creatorcontrib>Yen, Che-Hung</creatorcontrib><creatorcontrib>Yeh, Yi-Wei</creatorcontrib><creatorcontrib>Liang, Chih-Sung</creatorcontrib><creatorcontrib>Ho, Pei-Shen</creatorcontrib><creatorcontrib>Kuo, Shin-Chang</creatorcontrib><creatorcontrib>Huang, Chang-Chih</creatorcontrib><creatorcontrib>Chen, Chun-Yen</creatorcontrib><creatorcontrib>Shih, Mei-Chen</creatorcontrib><creatorcontrib>Ma, Kuo-Hsing</creatorcontrib><creatorcontrib>Peng, Giia-Sheun</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><title>Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p &lt; 0.001), as well as diminished performance on the WCST (p &lt; 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.</description><subject>Age</subject><subject>Alcoholism</subject><subject>Alcoholism - metabolism</subject><subject>Alcohols</subject><subject>Amphetamines</subject><subject>Availability</subject><subject>Brain</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Cognition</subject><subject>Cognition &amp; reasoning</subject><subject>Cognition Disorders - metabolism</subject><subject>Cognitive ability</subject><subject>Demography</subject><subject>Dopamine</subject><subject>Dopamine Plasma Membrane Transport Proteins - metabolism</subject><subject>Dopamine transporter</subject><subject>Drug dependence</subject><subject>Geriatrics</subject><subject>Human subjects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Organotechnetium Compounds - metabolism</subject><subject>Patients</subject><subject>Personality</subject><subject>Personality traits</subject><subject>Phenols (Class of compounds)</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Smoking</subject><subject>Statistics, Nonparametric</subject><subject>Studies</subject><subject>Subgroups</subject><subject>Tomography</subject><subject>Tropanes - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01vEzEQhlcIREvhHyBYCQnBIcHeD699qRS1fFQqFJXC1ZrYs4kjxw62N9B_j0PSqkE9IB9sjZ95x37tKYrnlIxp3dF3Cz8EB3a88g7HhNaU0O5BcUhFXY1YReqHd9YHxZMYF4S0NWfscXFQMVoR3nSHhbtEPSjU5alfwdI4LK8CuLjyIWEoJ2swFqbGmnRdgtPlFxyCV37mTDJrLE-xN8qkWBpXfgaL5VdIBl0O_DJpXk6s8nNvM7ZCp9EpfFo86sFGfLabj4rvH95fnXwanV98PDuZnI8UE1Ua1Zy3U6h5zRAoMtYwQRRgRYBVumdUE00F1rxvGEx7IEwxLURDVUWEgKatj4qXW92V9VHurIqSZnVChWirTJxtCe1hIVfBLCFcSw9G_g34MJMQklEWJW_7Vk0r2nesa6ZKA--BVlXbdho7QJW1jnfVhukStcoOBLB7ovs7zszlzK9l0_BOiC4LvNkJBP9zwJjk0kSF1oJDP2zP3bW0ETyjr_5B77_djprlV5HG9T7XVRtROWmo4JzWvMnU-B4qD41Lo_K_6k2O7yW83UvITMLfaQZDjPLs2-X_sxc_9tnXd9g5gk3z6O2QjHdxH2y2oAo-xoD9rcmUyE1b3LghN20hd22R017cfaDbpJs-qP8AdgEIww</recordid><startdate>20150629</startdate><enddate>20150629</enddate><creator>Yen, Che-Hung</creator><creator>Yeh, Yi-Wei</creator><creator>Liang, Chih-Sung</creator><creator>Ho, Pei-Shen</creator><creator>Kuo, Shin-Chang</creator><creator>Huang, Chang-Chih</creator><creator>Chen, Chun-Yen</creator><creator>Shih, Mei-Chen</creator><creator>Ma, Kuo-Hsing</creator><creator>Peng, Giia-Sheun</creator><creator>Lu, Ru-Band</creator><creator>Huang, San-Yuan</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150629</creationdate><title>Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence</title><author>Yen, Che-Hung ; Yeh, Yi-Wei ; Liang, Chih-Sung ; Ho, Pei-Shen ; Kuo, Shin-Chang ; Huang, Chang-Chih ; Chen, Chun-Yen ; Shih, Mei-Chen ; Ma, Kuo-Hsing ; Peng, Giia-Sheun ; Lu, Ru-Band ; Huang, San-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age</topic><topic>Alcoholism</topic><topic>Alcoholism - metabolism</topic><topic>Alcohols</topic><topic>Amphetamines</topic><topic>Availability</topic><topic>Brain</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Cognition</topic><topic>Cognition &amp; reasoning</topic><topic>Cognition Disorders - metabolism</topic><topic>Cognitive ability</topic><topic>Demography</topic><topic>Dopamine</topic><topic>Dopamine Plasma Membrane Transport Proteins - metabolism</topic><topic>Dopamine transporter</topic><topic>Drug dependence</topic><topic>Geriatrics</topic><topic>Human subjects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Memory</topic><topic>Mental disorders</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Organotechnetium Compounds - metabolism</topic><topic>Patients</topic><topic>Personality</topic><topic>Personality traits</topic><topic>Phenols (Class of compounds)</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Smoking</topic><topic>Statistics, Nonparametric</topic><topic>Studies</topic><topic>Subgroups</topic><topic>Tomography</topic><topic>Tropanes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yen, Che-Hung</creatorcontrib><creatorcontrib>Yeh, Yi-Wei</creatorcontrib><creatorcontrib>Liang, Chih-Sung</creatorcontrib><creatorcontrib>Ho, Pei-Shen</creatorcontrib><creatorcontrib>Kuo, Shin-Chang</creatorcontrib><creatorcontrib>Huang, Chang-Chih</creatorcontrib><creatorcontrib>Chen, Chun-Yen</creatorcontrib><creatorcontrib>Shih, Mei-Chen</creatorcontrib><creatorcontrib>Ma, Kuo-Hsing</creatorcontrib><creatorcontrib>Peng, Giia-Sheun</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yen, Che-Hung</au><au>Yeh, Yi-Wei</au><au>Liang, Chih-Sung</au><au>Ho, Pei-Shen</au><au>Kuo, Shin-Chang</au><au>Huang, Chang-Chih</au><au>Chen, Chun-Yen</au><au>Shih, Mei-Chen</au><au>Ma, Kuo-Hsing</au><au>Peng, Giia-Sheun</au><au>Lu, Ru-Band</au><au>Huang, San-Yuan</au><au>Hashimoto, Kenji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-29</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0131017</spage><epage>e0131017</epage><pages>e0131017-e0131017</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Dopamine plays an important role in the development of alcohol dependence, cognitive dysfunction, and is regulated via dopamine transporter activity. Although dopamine transporter activity is critically involved in alcohol dependence, studies observing this relationship are limited. Thus the current study examined whether dopamine transporter availability is associated with developing of alcohol dependence and cognitive dysfunction. Brain imaging with 99mTc-TRODAT-1 as a ligand was used to measure dopamine transporter availability among 26 male patients with pure alcohol dependence and 22 age- and sex- matched healthy volunteers. The Wisconsin Card Sorting Test (WCST) and Tridimensional Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively. Compared to healthy controls, patients with alcohol dependence showed a significant reduction in dopamine transporter availability (p &lt; 0.001), as well as diminished performance on the WCST (p &lt; 0.001). Dopamine transporter availability was negatively correlated with both total and perseverative WCST errors among healthy controls, but only patients with alcohol dependence showed a positive correlation between dopamine transporter availability and a harm avoidance personality profile. Thus, reductions in dopamine transporter availability may play a pathophysiological role in the development of pure alcohol dependence, given its association with neurocognitive deficits. Moreover, personality may influence the development of pure alcohol dependence; however, additional clinical subgroups should be examined to confirm this possibility.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26120847</pmid><doi>10.1371/journal.pone.0131017</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2015-06, Vol.10 (6), p.e0131017-e0131017
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1692019952
source Publicly Available Content (ProQuest); PubMed Central
subjects Age
Alcoholism
Alcoholism - metabolism
Alcohols
Amphetamines
Availability
Brain
Brain research
Case-Control Studies
Cognition
Cognition & reasoning
Cognition Disorders - metabolism
Cognitive ability
Demography
Dopamine
Dopamine Plasma Membrane Transport Proteins - metabolism
Dopamine transporter
Drug dependence
Geriatrics
Human subjects
Humans
Male
Medical imaging
Memory
Mental disorders
Neuroimaging
Neurosciences
Organotechnetium Compounds - metabolism
Patients
Personality
Personality traits
Phenols (Class of compounds)
Psychiatry
Schizophrenia
Smoking
Statistics, Nonparametric
Studies
Subgroups
Tomography
Tropanes - metabolism
title Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T05%3A56%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reduced%20Dopamine%20Transporter%20Availability%20and%20Neurocognitive%20Deficits%20in%20Male%20Patients%20with%20Alcohol%20Dependence&rft.jtitle=PloS%20one&rft.au=Yen,%20Che-Hung&rft.date=2015-06-29&rft.volume=10&rft.issue=6&rft.spage=e0131017&rft.epage=e0131017&rft.pages=e0131017-e0131017&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0131017&rft_dat=%3Cgale_plos_%3EA419881384%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-3885ba3836ea1e664690cae20a62df61d0d19e38f46abfa06c6d9941c2099a453%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1692019952&rft_id=info:pmid/26120847&rft_galeid=A419881384&rfr_iscdi=true