Interrelationship of Multiple Endothelial Dysfunction Biomarkers with Chronic Kidney Disease

The interrelationship of multiple endothelial biomarkers and chronic kidney disease (CKD) has not been well studied. We measured asymmetric dimethylarginine (ADMA), L-arginine, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE...

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Published in:PloS one 2015-07, Vol.10 (7), p.e0132047-e0132047
Main Authors: Chen, Jing, Hamm, L Lee, Mohler, Emile R, Hudaihed, Alhakam, Arora, Robin, Chen, Chung-Shiuan, Liu, Yanxi, Browne, Grace, Mills, Katherine T, Kleinpeter, Myra A, Simon, Eric E, Rifai, Nader, Klag, Michael J, He, Jiang
Format: Article
Language:English
Subjects:
Adhesion
Adhesion tests
Adult
Aged
Albuminuria - blood
Albuminuria - urine
Analysis
Arginine
Arginine - analogs & derivatives
Arginine - blood
Atherosclerosis
Biological markers
Biomarkers
Blood Glucose - analysis
Cardiovascular disease
Cell adhesion
Cell Adhesion Molecules - blood
Chronic kidney failure
Comorbidity
Creatinine - analysis
Diabetes
Diabetes Mellitus - blood
Diabetes Mellitus - epidemiology
Dilation
E-selectin
Endothelium
Endothelium, Vascular - physiopathology
Epidemiology
Female
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - epidemiology
Hypertension
Hypertension - blood
Hypertension - epidemiology
Inflammation
Intercellular adhesion molecule 1
Kidney diseases
Kidney Function Tests
Kidneys
Lipids - blood
Male
Medicine
Middle Aged
Multivariable control
Nitrates
Nitric oxide
Nitric Oxide - metabolism
Nitroglycerin
Patients
Peritoneal dialysis
Public health
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Risk
Sensitivity and Specificity
Studies
Thrombophilia - blood
Thrombophilia - etiology
Transplants & implants
Vasodilation
Von Willebrand factor
von Willebrand Factor - analysis
Young Adult
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Summary:The interrelationship of multiple endothelial biomarkers and chronic kidney disease (CKD) has not been well studied. We measured asymmetric dimethylarginine (ADMA), L-arginine, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), von Willebrand factor (vWF), flow-mediated dilation (FMD), and nitroglycerin-induced dilation (NID) in 201 patients with CKD and 201 community-based controls without CKD. Multivariable analyses were used to examine the interrelationship of endothelial biomarkers with CKD. The multivariable-adjusted medians (interquartile ranges) were 0.54 (0.40, 0.75) in patients with CKD vs. 0.25 (0.22, 0.27) μmol /L in controls without CKD (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0132047