Association of DNA Methylation with Acute Mania and Inflammatory Markers

In order to determine whether epigenetic changes specific to the manic mood state can be detected in peripheral blood samples we assayed DNA methylation levels genome-wide in serum samples obtained from 20 patients hospitalized for mania and 20 unaffected controls using the Illumina 450K methylation...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0132001-e0132001
Main Authors: Sabunciyan, Sarven, Maher, Brion, Bahn, Sabine, Dickerson, Faith, Yolken, Robert H
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Affective disorders
Aged
Alcohol
Behavior disorders
Biomarkers - blood
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - pathology
Brain research
Cholesterol Side-Chain Cleavage Enzyme - metabolism
Comparative analysis
Cytochrome P-450
Deoxyribonucleic acid
DNA
DNA Methylation
Drug use
Epigenetic inheritance
Epigenetics
Female
Gastric cancer
Genetic Loci
Genetic research
Genomes
Genomics
Humans
Hypotheses
Inflammation
Inflammation Mediators - blood
Loci
Male
Mania
Markers
Medical prognosis
Methylation
Middle Aged
Mood
Patients
Pediatrics
Peripheral blood
Prostate
Schizophrenia
Stomach cancer
Tumor necrosis factor-TNF
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Summary:In order to determine whether epigenetic changes specific to the manic mood state can be detected in peripheral blood samples we assayed DNA methylation levels genome-wide in serum samples obtained from 20 patients hospitalized for mania and 20 unaffected controls using the Illumina 450K methylation arrays. We identified a methylation locus in the CYP11A1 gene, which is regulated by corticotropin, that is hypo-methylated in individuals hospitalized for mania compared with unaffected controls. DNA methylation levels at this locus appear to be state related as levels in follow-up samples collected from mania patients six months after hospitalization were similar to those observed in controls. In addition, we found that methylation levels at the CYP11A1 locus were significantly correlated with three inflammatory markers in serum in acute mania cases but not in unaffected controls. We conclude that mania is associated with alterations in levels of DNA methylation and inflammatory markers. Since epigenetic markers are potentially malleable, a better understanding of the role of epigenetics may lead to new methods for the prevention and treatment of mood disorders.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0132001