Risk Factors of Coronary Artery Disease in Secondary Prevention--Results from the AtheroGene--Study

Risk factors are important in cardiovascular (CV) medicine for risk stratification of patients. We aimed to compare the traditional risk factors to clinical variables for the prediction of secondary cardiovascular events. For this study, 3229 patients with known coronary artery disease (CAD) were in...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0131434-e0131434
Main Authors: Zengin, Elvin, Bickel, Christoph, Schnabel, Renate B, Zeller, Tanja, Lackner, Karl-J, Rupprecht, Hans-J, Blankenberg, Stefan, Westermann, Dirk
Format: Article
Language:English
Subjects:
Cardiovascular disease
Cardiovascular diseases
Cohort Studies
Confidence intervals
Coronary artery
Coronary artery disease
Coronary Artery Disease - epidemiology
Coronary Artery Disease - prevention & control
Creatinine
Diabetes mellitus
Disease prevention
Female
Follow-Up Studies
Health risk assessment
Health risks
Heart diseases
High density lipoprotein
Humans
Hypertension
Low density lipoprotein
Male
Mathematical analysis
Middle Aged
Mortality
Myocardial infarction
Patients
Proportional Hazards Models
Regression Analysis
Risk analysis
Risk Factors
Risk management
Secondary Prevention
Smoking
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Summary:Risk factors are important in cardiovascular (CV) medicine for risk stratification of patients. We aimed to compare the traditional risk factors to clinical variables for the prediction of secondary cardiovascular events. For this study, 3229 patients with known coronary artery disease (CAD) were included. We calculated whether the traditional risk factors, diabetes mellitus, increased LDL/HDL ratio, arterial hypertension and smoking alone and in combination with the clinical variables, ejection fraction, creatinine clearance, multi-vessel disease and CRP concentration predict the outcome cardiovascular death or non-fatal myocardial infarction (N = 432) during the mean follow-up time of 4.2 ± 2.0 years. In this cohort diabetes mellitus was the risk factor with the strongest influence regarding occurrence of secondary events (hazard ratio; HR:1.70, confidence interval; CI 95%: 1.36-2.11; P0.0001) or calculated creatinine clearence (Cockroft-Gault formula) (HR:2.26 CI 95%:1.78-2.89; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0131434