Low Serum Neutrophil Gelatinase-associated Lipocalin Level as a Marker of Malnutrition in Maintenance Hemodialysis Patients

Neutrophil gelatinase-associated lipocalin (NGAL or LCN2) is an iron-transporting factor which possesses various activities such as amelioration of kidney injury and host defense against pathogens. Its circulating concentrations are elevated in acute and chronic kidney diseases and show a positive c...

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Published in:PloS one 2015-07, Vol.10 (7), p.e0132539-e0132539
Main Authors: Imamaki, Hirotaka, Ishii, Akira, Yokoi, Hideki, Kasahara, Masato, Kuwabara, Takashige, Mori, Keita P, Kato, Yukiko, Kuwahara, Takashi, Satoh, Masugi, Nakatani, Kimihiko, Saito, Yoshihiko, Tomosugi, Naohisa, Sugawara, Akira, Nakao, Kazuwa, Mukoyama, Masashi, Yanagita, Motoko, Mori, Kiyoshi
Format: Article
Language:English
Subjects:
Acute-Phase Proteins
Age Factors
Aged
Albumin
Analysis
Antimicrobial agents
Aorta - metabolism
Biomarkers - blood
Blood
Chronic kidney failure
Confidence intervals
Correlation
Creatinine
Development and progression
Dialysis
Diet
Dietary intake
Disease Progression
Enzyme-linked immunosorbent assay
Enzymes
Female
Ferritin
Follow-Up Studies
Gelatinase
Gene expression
Health aspects
Hemodialysis
Hemoglobin
Hemoglobins
Hepcidin
Homeostasis
Hospitals
Humans
Infection
Infections
Inflammation - pathology
Internal medicine
Iron
Iron - administration & dosage
Iron - pharmacology
Kidney diseases
Kidneys
Linear Models
Lipocalin
Lipocalin-2
Lipocalins - blood
Maintenance
Male
Malnutrition
Malnutrition - blood
Medicine
Middle Aged
Morbidity
Mortality
Multivariate Analysis
Muscles
Nephrology
Neutrophils
Nutrition
Parenteral nutrition
Patients
Peripheral blood
Physiology
Proto-Oncogene Proteins - blood
Regression analysis
Renal Dialysis
Renal Veins - metabolism
Serum albumin
Serum Albumin - metabolism
Statistical analysis
Transplants & implants
University graduates
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Summary:Neutrophil gelatinase-associated lipocalin (NGAL or LCN2) is an iron-transporting factor which possesses various activities such as amelioration of kidney injury and host defense against pathogens. Its circulating concentrations are elevated in acute and chronic kidney diseases and show a positive correlation with poor renal outcome and mortality, but its clinical significance in maintenance hemodialysis (HD) patients remains elusive. Serum NGAL levels were determined by enzyme-linked immunosorbent assay in out-patient, Japanese HD subjects. Their correlation to laboratory findings and morbidity (as development of severe infection or serum albumin reduction) was investigated using linear regression analysis and χ2 test. Pre-dialysis serum NGAL levels in HD patients were elevated by 13-fold compared to healthy subjects (n=8, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0132539