Treatment of Oral Multispecies Biofilms by an Anti-Biofilm Peptide

Human oral biofilms are multispecies microbial communities that exhibit high resistance to antimicrobial agents. Dental plaque gives rise to highly prevalent and costly biofilm-related oral infections, which lead to caries or other types of oral infections. We investigated the ability of the recentl...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0132512-e0132512
Main Authors: Wang, Zhejun, de la Fuente-Núñez, Cesar, Shen, Ya, Haapasalo, Markus, Hancock, Robert E W
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobial agents
Antimicrobial Cationic Peptides - pharmacology
Bacteria
Bacterial infections
Biofilms
Biofilms - drug effects
Cell death
Chlorhexidine
Chlorhexidine - pharmacology
Chromatography
Combined treatment
Composite materials
Confocal
Confocal microscopy
Cyclohexane
Dental caries
Dental plaque
Dental Plaque - drug therapy
Dental Plaque - microbiology
Dentistry
Disinfection
Dose-Response Relationship, Drug
Drug Therapy, Combination
Electron microscopy
Enterococcus faecalis - drug effects
Gene expression
Gram-positive bacteria
Health aspects
High resistance
Humans
Hydroxyapatite
Immunology
Infections
Laboratories
Lysis
Microbial activity
Microorganisms
Microscopy, Confocal
Microscopy, Electron, Scanning
Mouthwashes - pharmacology
Oral diseases
Peptides
Saliva
Scanning electron microscopy
Statistical analysis
Streptococcus infections
Streptococcus mutans - drug effects
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Summary:Human oral biofilms are multispecies microbial communities that exhibit high resistance to antimicrobial agents. Dental plaque gives rise to highly prevalent and costly biofilm-related oral infections, which lead to caries or other types of oral infections. We investigated the ability of the recently identified anti-biofilm peptide 1018 to induce killing of bacterial cells present within oral multispecies biofilms. At 10 μg/ml (6.5 μM), peptide 1018 was able to significantly (p50% of the biofilm being killed and >35% being dispersed in only 3 minutes. Peptide 1018 may potentially be used by itself or in combination with CHX as a non-toxic and effective anti-biofilm agent for plaque disinfection in clinical dentistry.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0132512