Interleukin-6 as a Prognostic Biomarker in Ruptured Intracranial Aneurysms

• Published in: PloS one 2015-07, Vol.10 (7), p.e0132115-e0132115
• Main Authors: Kao, Hung-Wen, Lee, Kwo-Whei, Kuo, Chen-Ling, Huang, Ching-Shan, Tseng, Wan-Min, Liu, Chin-San, Lin, Ching-Po
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aneurysm; Aneurysm, Ruptured - diagnosis; Aneurysm, Ruptured - pathology; Aneurysm, Ruptured - therapy; Aneurysms; Area Under Curve; Biomarkers; Biomarkers - blood; Blood; Cancer; Cerebrospinal fluid; Clinical outcomes; Coils; Coma; Correlation; Cytokines; Diabetes; Embolization; Embolization, Therapeutic; Female; Glasgow Coma Scale; Hemorrhage; Hospitals; Humans; Inflammation; Interleukin; Interleukin 6; Interleukin-6 - blood; Interleukin-6 - cerebrospinal fluid; Intracranial Aneurysm - diagnosis; Intracranial Aneurysm - pathology; Intracranial Aneurysm - therapy; Ischemia; Levels; Logistic Models; Male; Medical imaging; Middle Aged; Neurosurgery; Odds Ratio; Orifices; Patients; Platinum; Prognosis; Prospective Studies; Proteins; Quality; Regression analysis; Regression models; Risk analysis; Risk Factors; ROC Curve; Studies; Subarachnoid hemorrhage; Subarachnoid Hemorrhage - etiology; Subarachnoid Hemorrhage - pathology; Traumatic brain injury; Vasoconstriction; Veins & arteries
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0132115

Interleukin-6 (IL-6), a proinflammatory cytokine, was found to surge in the cerebral spinal fluid after aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that the plasma level of IL-6 could be an independent biomarker in predicting clinical outcome of patients with ruptured intracranial aneurysm. We prospectively included 53 consecutive patients treated with platinum coil embolization of the ruptured intracranial aneurysm. Plasma IL-6 levels were measured in the blood samples at the orifices of the aneurysms and from peripheral veins. The outcome measure was the modified Rankin Scale one month after SAH. Multiple logistic regression analyses were used to evaluate the associations between the plasma IL-6 levels and the neurological outcome. Significant risk factors for the poor outcome were old age, low Glasgow Coma Scale (GCS) on day 0, high Fisher grades, and high aneurysmal and venous IL-6 levels in univariate analyses. Aneurysmal IL-6 levels showed modest to moderate correlations with GCS on day 0, vasospasm grade and Fisher grade. A strong correlation was found between the aneurysmal and the corresponding venous IL-6 levels (ρ = 0.721; P