Host Delivery of Favorite Meals for Intracellular Pathogens

  [...]a robust continuous host nutrient supply pipeline within viable host cells is essential to meet the energy demands of intravacuolar pathogens that also face the challenge of importing across the pathogen-containing vacuole. [...]the metabolic responses observed in tissue culture may vary cons...

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Bibliographic Details
Published in:PLoS pathogens 2015-06, Vol.11 (6), p.e1004866-e1004866
Main Authors: Abu Kwaik, Yousef, Bumann, Dirk
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Animals
Bacteriology
Biomass
Carbon
E coli
Energy resources
Host-Pathogen Interactions - physiology
Humans
Hypoxia
Infections
Metabolism
Metabolites
Nitrogen
Pearls
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Summary:  [...]a robust continuous host nutrient supply pipeline within viable host cells is essential to meet the energy demands of intravacuolar pathogens that also face the challenge of importing across the pathogen-containing vacuole. [...]the metabolic responses observed in tissue culture may vary considerably from the in vivo environment. [...]in response to hypoxia encountered within inflammatory foci, the cells respond to it through up-regulation of the hypoxia inducible factor (HIF-1) [38,39], which activates hundreds of genes required for adaption to hypoxia, including the glucose transporter and glycolytic enzymes as well as lactate dehydrogenase [5,40].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004866