Host Delivery of Favorite Meals for Intracellular Pathogens

  [...]a robust continuous host nutrient supply pipeline within viable host cells is essential to meet the energy demands of intravacuolar pathogens that also face the challenge of importing across the pathogen-containing vacuole. [...]the metabolic responses observed in tissue culture may vary cons...

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Published in:PLoS pathogens 2015-06, Vol.11 (6), p.e1004866-e1004866
Main Authors: Abu Kwaik, Yousef, Bumann, Dirk
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Animals
Bacteriology
Biomass
Carbon
E coli
Energy resources
Host-Pathogen Interactions - physiology
Humans
Hypoxia
Infections
Metabolism
Metabolites
Nitrogen
Pearls
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cited_by cdi_FETCH-LOGICAL-c498t-ce461552d0902220f93ee0f99afb6d243d38917eb8143a6693c6a5d8468071a53
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description   [...]a robust continuous host nutrient supply pipeline within viable host cells is essential to meet the energy demands of intravacuolar pathogens that also face the challenge of importing across the pathogen-containing vacuole. [...]the metabolic responses observed in tissue culture may vary considerably from the in vivo environment. [...]in response to hypoxia encountered within inflammatory foci, the cells respond to it through up-regulation of the hypoxia inducible factor (HIF-1) [38,39], which activates hundreds of genes required for adaption to hypoxia, including the glucose transporter and glycolytic enzymes as well as lactate dehydrogenase [5,40].
doi_str_mv 10.1371/journal.ppat.1004866
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subjects Acquisitions & mergers
Animals
Bacteriology
Biomass
Carbon
E coli
Energy resources
Host-Pathogen Interactions - physiology
Humans
Hypoxia
Infections
Metabolism
Metabolites
Nitrogen
Pearls
title Host Delivery of Favorite Meals for Intracellular Pathogens
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