Structured Treatment Interruptions and Low Doses of IL-2 in Patients with Primary HIV Infection. Inflammatory, Virological and Immunological Outcomes

Interventions during primary HIV infection (PHI) can modify the clinical course during the chronic phase. The long-term effect of structured treatment interruptions (STI) followed by low doses of interleukin-2 (IL-2) in treated PHI patients is unknown. Twelve PHI patients with viral load (VL) 500 ce...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0131651-e0131651
Main Authors: Sued, Omar, Ambrosioni, Juan, Nicolás, David, Manzardo, Christian, Agüero, Fernando, Claramonte, Xavier, Plana, Montserrat, Tuset, Montserrat, Pumarola, Tomás, Gallart, Teresa, Gatell, José María, Miró, José María
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Anti-HIV Agents - administration & dosage
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiretrovirals
Care and treatment
CD38 antigen
CD4 antigen
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD8 antigen
Cell Proliferation
Chronic infection
Clinical trials
Cytokines
Drug Administration Schedule
Drug resistance
Drug Resistance, Viral
Drug therapy
Female
Highly active antiretroviral therapy
HIV
HIV (Viruses)
HIV infections
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV patients
Human immunodeficiency virus
Humans
Immune response
Immunology
Immunotherapy
Infeccions per VIH
Infections
Infectious diseases
Inflamació
Inflammation
Interleukin 2
Interleukin-2 - administration & dosage
Interleukins
Male
Males
Patient outcomes
Patients
Resposta immunitària
Sexually transmitted diseases
STD
Treatment Outcome
VIH (Virus)
Viral Load
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Summary:Interventions during primary HIV infection (PHI) can modify the clinical course during the chronic phase. The long-term effect of structured treatment interruptions (STI) followed by low doses of interleukin-2 (IL-2) in treated PHI patients is unknown. Twelve PHI patients with viral load (VL) 500 cells/mm3, and CD4/CD8 ratio >1, on antiretroviral therapy (ART) initiated within the first 90 days of infection and continued for at least 12 months were included. They underwent four STI and were then allocated (week 0 of the study) to ART alone or ART plus low doses of IL-2. ART was stopped once VL
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0131651