A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism rs3775291 in Toll-Like Receptor 3 and Breast Cancer Relapse

Toll-like receptors (TLRs) regulate the balance between the innate and adaptive immune responses. Missense single nucleotide polymorphisms (SNPs) in TLRs might be functional and thus influence the risks of chronic infection and cancer development. Here, we investigated the association of two missens...

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Bibliographic Details
Published in:PloS one 2015-07, Vol.10 (7), p.e0133184-e0133184
Main Authors: Chen, Dan-Na, Song, Chuan-Gui, Yu, Ke-Da, Jiang, Yi-Zhou, Ye, Fu-Gui, Shao, Zhi-Ming
Format: Article
Language:English
Subjects:
Adaptive immunity
Adult
Analysis
Asian Continental Ancestry Group - genetics
Biomarkers, Tumor - genetics
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Cancer therapies
China - epidemiology
Chromosomes
Development and progression
Disease-Free Survival
Female
Gene expression
Genes, Dominant
Genes, Recessive
Genetic aspects
Genotypes
Health aspects
Hospitals
Humans
Immune response
Infection
Kaplan-Meier Estimate
Laboratories
Lung cancer
Medical prognosis
Medical research
Metastasis
Middle Aged
Models, Genetic
Mutation
Mutation, Missense
Neoplasm Recurrence, Local - genetics
Polymorphism, Single Nucleotide
Prospective Studies
Prostate cancer
Recurrence (Disease)
Single nucleotide polymorphisms
Studies
Surgery
Toll-Like Receptor 1 - genetics
Toll-Like Receptor 3 - genetics
Toll-like receptors
Triple Negative Breast Neoplasms - genetics
Triple Negative Breast Neoplasms - mortality
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Summary:Toll-like receptors (TLRs) regulate the balance between the innate and adaptive immune responses. Missense single nucleotide polymorphisms (SNPs) in TLRs might be functional and thus influence the risks of chronic infection and cancer development. Here, we investigated the association of two missense SNPs, rs3775291 (c.1234G>A) in the TLR3 gene and rs4833095 (c.743T>C) in the TLR1 gene, with relapse-free survival (RFS) in a cohort of prospectively observed breast cancer patients. In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population. Univariate analysis revealed that the patients with the AA genotype of rs3775291 had a shorter RFS compared with those carrying the G allele in the recessive model (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0133184