Endometrial Endometrioid Carcinoma Metastases Show Decreased ER-Alpha and PR-A Expression Compared to Matched Primary Tumors

Patients with endometrial endometrioid carcinoma (EEC) that present with advanced primary disease and develop recurrences have a poor outcome. The phenotype of EEC metastases and recurrences is poorly studied. We evaluated the morphological features and ER-alpha/PRA/p53 immunohistochemical expressio...

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Bibliographic Details
Published in:PloS one 2015-08, Vol.10 (8), p.e0134969-e0134969
Main Authors: Bartosch, Carla, Monteiro-Reis, Sara, Vieira, Renata, Pereira, Armindo, Rodrigues, Marta, Jerónimo, Carmen, Lopes, José M
Format: Article
Language:English
Subjects:
Biology
Breast cancer
Cancer metastasis
Cancer therapies
Carcinoma, Endometrioid - metabolism
Carcinoma, Endometrioid - pathology
Carcinoma, Endometrioid - secondary
Cloning
Deoxyribonucleic acid
DNA
DNA methylation
DNA Methylation - genetics
Endocrine therapy
Endometrial cancer
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
Endometrial Neoplasms - secondary
Endometrium
Epigenetics
Estrogen Receptor alpha - genetics
Estrogen Receptor alpha - metabolism
Estrogens
Etiology
Female
Gene expression
Genetic aspects
Hormones
Humans
Immunohistochemistry
Immunology
Medical prognosis
Medical research
Metastases
Metastasis
Methylation
Middle Aged
Oncology
p53 Protein
Pathology
Patients
Phenotypes
Promoter Regions, Genetic - genetics
Receptors, Progesterone - genetics
Receptors, Progesterone - metabolism
Tumor proteins
Tumor Suppressor Protein p53 - metabolism
Tumors
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Description
Summary:Patients with endometrial endometrioid carcinoma (EEC) that present with advanced primary disease and develop recurrences have a poor outcome. The phenotype of EEC metastases and recurrences is poorly studied. We evaluated the morphological features and ER-alpha/PRA/p53 immunohistochemical expression of a sample of 45 EEC metastases compared to matched primary tumors. Additionally, we studied methylation levels of ER-alpha/PRA gene promoters. The distribution of histological FIGO grade was significantly different in metastases, which disclosed higher grade than primary tumors (p = 0.005). Mitotic index was significantly lower in metastases compared to matched primary tumors (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0134969