RNA Virus Reassortment: An Evolutionary Mechanism for Host Jumps and Immune Evasion

  Virus reassortment, or simply reassortment, is a process of genetic recombination that is exclusive to segmented RNA viruses in which co-infection of a host cell with multiple viruses may result in the shuffling of gene segments to generate progeny viruses with novel genome combinations (Fig 1A) [...

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Bibliographic Details
Published in:PLoS pathogens 2015-07, Vol.11 (7), p.e1004902-e1004902
Main Authors: Vijaykrishna, Dhanasekaran, Mukerji, Reshmi, Smith, Gavin J D
Format: Article
Language:English
Subjects:
Animals
Biological Evolution
Genes
Host-Parasite Interactions - genetics
Host-Parasite Interactions - immunology
Humans
Immune Evasion - genetics
Immune Evasion - immunology
Influenza
Mutation
Pandemics
Pearls
Reassortant Viruses - genetics
Reassortant Viruses - immunology
RNA Virus Infections - genetics
RNA Virus Infections - immunology
RNA Viruses - genetics
RNA Viruses - immunology
Studies
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Summary:  Virus reassortment, or simply reassortment, is a process of genetic recombination that is exclusive to segmented RNA viruses in which co-infection of a host cell with multiple viruses may result in the shuffling of gene segments to generate progeny viruses with novel genome combinations (Fig 1A) [1]. Despite a lack of a mechanistic understanding of the function of packaging signals, these observational studies highlight important implications for viral evolution through epistatic interaction between gene segments and the emergence of novel reassortants.\n In addition, several distance-based methods exist [27], where degrees of similarity between pairs of viral genomes are used to infer reassortment [36,37].
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004902