Extracellular Virions: The Advance Guard of Poxvirus Infections

  The danger signals might include interferons, proinflammatory cytokines, or pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). [...]poxvirus vaccine vectors that cannot produce EVs, either because of viral replication deficiency or because of a defect in a gene needed...

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Bibliographic Details
Published in:PLoS pathogens 2015-07, Vol.11 (7), p.e1004904-e1004904
Main Author: Pickup, David J
Format: Article
Language:English
Subjects:
Animals
Cytokines
Guards
HIV
Host-Parasite Interactions - immunology
Human immunodeficiency virus
Humans
Infections
Pearls
Poxviridae - immunology
Poxviridae - pathogenicity
Poxviridae Infections - immunology
Proteins
Vaccines
Virion - immunology
Viruses
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Summary:  The danger signals might include interferons, proinflammatory cytokines, or pathogen-associated and damage-associated molecular patterns (PAMPs and DAMPs). [...]poxvirus vaccine vectors that cannot produce EVs, either because of viral replication deficiency or because of a defect in a gene needed for EV formation, may benefit from a lack of EV-mediated suppression of immune responses towards these vaccines.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1004904