Intracochlear Bleeding Enhances Cochlear Fibrosis and Ossification: An Animal Study

• Published in: PloS one 2015-08, Vol.10 (8), p.e0136617-e0136617
• Main Authors: Ryu, Kyeung A, Lyu, Ah-Ra, Park, Heesung, Choi, Jin Woong, Hur, Gang Min, Park, Yong-Ho
• Format: Article
• Language: English
• Subjects: Animals; Auditory Threshold; Bleeding; Blood; Brain stem; Cochlea; Cochlea - surgery; Cochlear Implantation - adverse effects; Cochlear implants; Comparative analysis; Cytokines; Cytokines - metabolism; Disease Models, Animal; Ear; Ear surgery; Ears & hearing; Electrodes; Evoked Potentials, Auditory, Brain Stem; Fibrosis; Fibrosis - etiology; Fibrosis - metabolism; Fibrosis - pathology; Gene expression; Guinea Pigs; Hair cells; Hair Cells, Auditory - pathology; Health aspects; Hearing Disorders - etiology; Hearing Disorders - metabolism; Hearing Disorders - pathology; Hearing loss; Hemorrhage - complications; Hydrogels; Inflammation; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Inflammatory response; Interleukin 10; Male; Medical research; Medicine; Nitric oxide; Nitric-oxide synthase; Ossification; Ossification, Heterotopic - etiology; Ossification, Heterotopic - metabolism; Ossification, Heterotopic - pathology; Otolaryngology; Postoperative Complications; Risk factors; Studies; Surgery; Transplants & implants; Tumor necrosis factor-α
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0136617

The aim of this study was to investigate the effects of intracochlear bleeding during cochleostomy on cochlear inflammatory response and residual hearing in a guinea pig animal model. Auditory brainstem response threshold shifts were greater in blood injected ears (p