Improving Assessment of Lipoprotein Profile in Type 1 Diabetes by 1H NMR Spectroscopy

Patients with type 1 diabetes (T1D) present increased risk of cardiovascular disease (CVD). The aim of this study is to improve the assessment of lipoprotein profile in patients with T1D by using a robust developed method 1H nuclear magnetic resonance spectroscopy (1H NMR), for further correlation w...

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Published in:PloS one 2015-08, Vol.10 (8), p.e0136348-e0136348
Main Authors: Brugnara, Laura, Mallol, Roger, Ribalta, Josep, Vinaixa, Maria, Murillo, Serafín, Casserras, Teresa, Guardiola, Montse, Vallvé, Joan Carles, Kalko, Susana G, Correig, Xavier, Novials, Anna
Format: Article
Language:English
Subjects:
Adiposity
Adult
Alterations
Body composition
Body composition (biology)
Body fat
Body mass
Body Mass Index
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Cholesterol
Complications
Correlation
Diabetes Complications - blood
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes Mellitus, Type 1 - blood
Diet
Dual energy X-ray absorptiometry
Exercise
Female
Health risks
High density lipoprotein
Hip
Humans
Lipids
Lipoproteins
Lipoproteins (high density)
Lipoproteins (low density)
Lipoproteins (very low density)
Lipoproteins - blood
Low density lipoprotein
Magnetic resonance
Magnetic resonance spectroscopy
Male
NMR
NMR spectroscopy
Nuclear magnetic resonance
Nuclear Magnetic Resonance, Biomolecular
Patients
Physical activity
Sex Characteristics
Spectroscopy
Triglycerides
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Summary:Patients with type 1 diabetes (T1D) present increased risk of cardiovascular disease (CVD). The aim of this study is to improve the assessment of lipoprotein profile in patients with T1D by using a robust developed method 1H nuclear magnetic resonance spectroscopy (1H NMR), for further correlation with clinical factors associated to CVD. Thirty patients with T1D and 30 non-diabetes control (CT) subjects, matched for gender, age, body composition (DXA, BMI, waist/hip ratio), regular physical activity levels and cardiorespiratory capacity (VO2peak), were analyzed. Dietary records and routine lipids were assessed. Serum lipoprotein particle subfractions, particle sizes, and cholesterol and triglycerides subfractions were analyzed by 1H NMR. It was evidenced that subjects with T1D presented lower concentrations of small LDL cholesterol, medium VLDL particles, large VLDL triglycerides, and total triglycerides as compared to CT subjects. Women with T1D presented a positive association with HDL size (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0136348