Association of Pretreatment Anemia with Pathological Response and Survival of Breast Cancer Patients Treated with Neoadjuvant Chemotherapy: A Population-Based Study

Anemia related to adjuvant chemotherapy might predict compromised survival in patients with breast cancer. The present population-based study was to investigate the correlation of pretreatment anemia with pathological response and long-term prognosis of breast cancer patients receiving neoadjuvant c...

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Bibliographic Details
Published in:PloS one 2015-08, Vol.10 (8), p.e0136268-e0136268
Main Authors: Zhu, Wenjie, Xu, Binghe
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Adult
Aged
Anemia
Anemia - chemically induced
Anemia - complications
Biopsy
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Clinical outcomes
Complications and side effects
Confidence intervals
Correlation analysis
Endocrine therapy
Female
Health aspects
Hemoglobin
Hospitals
Humans
Hypoxia
Influence
Ionizing radiation
Logistic Models
Lymphatic system
Medical prognosis
Middle Aged
Mortality
Neoadjuvant Therapy - adverse effects
Neoadjuvant Therapy - methods
Patient outcomes
Patients
Population
Population studies
Population-based studies
Pretreatment
Prognosis
Proportional Hazards Models
Radiation therapy
Regression analysis
Regression models
Retrospective Studies
Statistical analysis
Studies
Subgroups
Surgery
Survival
Survival Analysis
Systematic review
Tumors
Ultrasonic imaging
Young Adult
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Summary:Anemia related to adjuvant chemotherapy might predict compromised survival in patients with breast cancer. The present population-based study was to investigate the correlation of pretreatment anemia with pathological response and long-term prognosis of breast cancer patients receiving neoadjuvant chemotherapy (NCT). From 1999 to 2011, a total of 655 patients with operable or locally advanced breast cancer who underwent NCT before definitive surgery were reviewed. The patients were subdivided into anemic (baseline hemoglobin (Hb)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0136268