Salivary Telomere Length and Lung Function in Adolescents Born Very Preterm: A Prospective Multicenter Study

Preterm birth is associated with abnormal respiratory functions throughout life. The mechanisms underlying these long-term consequences are still unclear. Shortening of telomeres was associated with many conditions, such as chronic obstructive pulmonary disease. We aimed to search for an association...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0136123-e0136123
Main Authors: Hadchouel, Alice, Marchand-Martin, Laetitia, Franco-Montoya, Marie-Laure, Peaudecerf, Laetitia, Ancel, Pierre-Yves, Delacourt, Christophe
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Adult
Adults
Aging
Air flow
Analysis
Biomarkers
Birth weight
Chronic obstructive pulmonary disease
Confounding Factors (Epidemiology)
Deoxyribonucleic acid
Disease
DNA
Dysplasia
Female
Genetic aspects
Gestational Age
Health aspects
Health risk assessment
Humans
Infant, Extremely Premature - metabolism
Lung - physiology
Lung diseases
Male
Newborn babies
Obstructive lung disease
Oxidative stress
Physiological aspects
Population
Population studies
Premature birth
Premature infants
Prospective Studies
Respiratory function
Respiratory Function Tests
Respiratory tract
Risk factors
Saliva - metabolism
Senescence
Sepsis
Studies
Task forces
Teenagers
Telomerase
Telomere Homeostasis
Telomeres
Values
Variables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Preterm birth is associated with abnormal respiratory functions throughout life. The mechanisms underlying these long-term consequences are still unclear. Shortening of telomeres was associated with many conditions, such as chronic obstructive pulmonary disease. We aimed to search for an association between telomere length and lung function in adolescents born preterm. Lung function and telomere length were measured in 236 adolescents born preterm and 38 born full-term from the longitudinal EPIPAGE cohort. Associations between telomere length and spirometric indices were tested in univariate and multivariate models accounting for confounding factors in the study population. Airflows were significantly lower in adolescents born preterm than controls; forced expiratory volume in one second was 12% lower in the extremely preterm born group than controls (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0136123