Asthma and COPD Overlap Syndrome (ACOS): A Systematic Review and Meta Analysis

The combination of asthma and chronic obstructive pulmonary disease (COPD), or ACOS is a recently defined syndrome. The epidemiology of the condition is poorly described and previous research has suggested ACOS is associated with worse outcomes than either condition alone. We therefore decided to co...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0136065-e0136065
Main Authors: Alshabanat, A, Zafari, Z, Albanyan, O, Dairi, M, FitzGerald, J M
Format: Article
Language:English
Subjects:
Airway management
Asthma
Asthma - complications
Asthma - drug therapy
Asthma - physiopathology
Body mass
Chronic obstructive pulmonary disease
Cohort Studies
Cross-Sectional Studies
Disease control
Epidemiology
Health care
Health services utilization
Humans
Literature reviews
Lung diseases
Medicine
Meta-analysis
Morbidity
Mortality
Obstructive lung disease
Older people
Population
Population studies
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - drug therapy
Pulmonary Disease, Chronic Obstructive - physiopathology
Quality of Life
Respiratory function
Respiratory Function Tests
Reviews
Smoking
Smoking - physiopathology
Studies
Systematic review
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Summary:The combination of asthma and chronic obstructive pulmonary disease (COPD), or ACOS is a recently defined syndrome. The epidemiology of the condition is poorly described and previous research has suggested ACOS is associated with worse outcomes than either condition alone. We therefore decided to complete a systematic review of the published literature. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta- Analyses guidelines. A structured search was performed in the PubMed, Embase, and Medline databases up to Feb 2015 to identify studies reporting incidence, prevalence, health care utilization, morbidity, or mortality in COPD and asthma. A total of 19 studies were included in the present study. The pooled prevalence of overlap among COPD was 27% (95% CI: 0.16-0.38, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0136065