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The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients

Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes c...

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Published in:PloS one 2015-09, Vol.10 (9), p.e0137127-e0137127
Main Authors: Wong, Ting Hway, Nguyen, Hai V, Chiu, Ming Terk, Chow, Khuan Yew, Ong, Marcus Eng Hock, Lim, Gek Hsiang, Nadkarni, Nivedita Vikas, Bautista, Dianne Carrol Tan, Cheng, Jolene Yu Xuan, Loo, Lynette Mee Ann, Seow, Dennis Chuen Chai
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cited_by cdi_FETCH-LOGICAL-c692t-b14d130f90cb74a7e5f8007f3e020664b15d8cfd940ff7722ba629916c466dae3
cites cdi_FETCH-LOGICAL-c692t-b14d130f90cb74a7e5f8007f3e020664b15d8cfd940ff7722ba629916c466dae3
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creator Wong, Ting Hway
Nguyen, Hai V
Chiu, Ming Terk
Chow, Khuan Yew
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Cheng, Jolene Yu Xuan
Loo, Lynette Mee Ann
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description Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients. Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings. Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p
doi_str_mv 10.1371/journal.pone.0137127
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Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients. Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings. Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p&lt;0.001), compared to other blunt trauma and higher fall heights. They were at higher risk of 12-month mortality (OR 1.75, 95% CI 1.18-2.58, p = 0.005), independent of ISS, RTS, age, gender, age-gender interaction and co-morbidities. Falls that were higher than 0.5m did not show this pattern. Males were at higher risk of mortality after low falls. The effect of age on mortality started at age 55 for males, and age 70 for females, and the difference was attributable to the additional mortality in male low-fallers. The low fall mechanism can optimize prediction of long-term mortality after moderate and severe injury, and may be a surrogate marker of frailty, complementing broader-based studies on aging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0137127</identifier><identifier>PMID: 26327646</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accidental Falls - mortality ; Adults ; Age ; Age factors ; Aged ; Aged, 80 and over ; Aging ; Biomarkers ; Body height ; Comorbidity ; Elderly patients ; Emergency medical services ; Emergency Service, Hospital ; Epidemiology ; Falls ; Female ; Females ; Fractures ; Fractures, Bone - mortality ; Frailty ; Gender differences ; Hip ; Hospital emergency services ; Humans ; Injuries ; Injury analysis ; Injury Severity Score ; Logistic Models ; Male ; Males ; Management ; Middle Aged ; Mortality ; Older people ; Patients ; Psychological aspects ; Registries ; Regression analysis ; Risk ; Sensitivity analysis ; Singapore ; Trauma ; Trauma Centers ; Wounds, Nonpenetrating - mortality</subject><ispartof>PloS one, 2015-09, Vol.10 (9), p.e0137127-e0137127</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Wong et al. 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Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients. Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings. Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p&lt;0.001), compared to other blunt trauma and higher fall heights. They were at higher risk of 12-month mortality (OR 1.75, 95% CI 1.18-2.58, p = 0.005), independent of ISS, RTS, age, gender, age-gender interaction and co-morbidities. Falls that were higher than 0.5m did not show this pattern. Males were at higher risk of mortality after low falls. The effect of age on mortality started at age 55 for males, and age 70 for females, and the difference was attributable to the additional mortality in male low-fallers. 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Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Ting Hway</au><au>Nguyen, Hai V</au><au>Chiu, Ming Terk</au><au>Chow, Khuan Yew</au><au>Ong, Marcus Eng Hock</au><au>Lim, Gek Hsiang</au><au>Nadkarni, Nivedita Vikas</au><au>Bautista, Dianne Carrol Tan</au><au>Cheng, Jolene Yu Xuan</au><au>Loo, Lynette Mee Ann</au><au>Seow, Dennis Chuen Chai</au><au>Olivier, Jake</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>10</volume><issue>9</issue><spage>e0137127</spage><epage>e0137127</epage><pages>e0137127-e0137127</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients. Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings. Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p&lt;0.001), compared to other blunt trauma and higher fall heights. They were at higher risk of 12-month mortality (OR 1.75, 95% CI 1.18-2.58, p = 0.005), independent of ISS, RTS, age, gender, age-gender interaction and co-morbidities. Falls that were higher than 0.5m did not show this pattern. Males were at higher risk of mortality after low falls. The effect of age on mortality started at age 55 for males, and age 70 for females, and the difference was attributable to the additional mortality in male low-fallers. The low fall mechanism can optimize prediction of long-term mortality after moderate and severe injury, and may be a surrogate marker of frailty, complementing broader-based studies on aging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26327646</pmid><doi>10.1371/journal.pone.0137127</doi><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1932-6203
ispartof PloS one, 2015-09, Vol.10 (9), p.e0137127-e0137127
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1719191753
source Publicly Available Content (ProQuest); PubMed Central
subjects Accidental Falls - mortality
Adults
Age
Age factors
Aged
Aged, 80 and over
Aging
Biomarkers
Body height
Comorbidity
Elderly patients
Emergency medical services
Emergency Service, Hospital
Epidemiology
Falls
Female
Females
Fractures
Fractures, Bone - mortality
Frailty
Gender differences
Hip
Hospital emergency services
Humans
Injuries
Injury analysis
Injury Severity Score
Logistic Models
Male
Males
Management
Middle Aged
Mortality
Older people
Patients
Psychological aspects
Registries
Regression analysis
Risk
Sensitivity analysis
Singapore
Trauma
Trauma Centers
Wounds, Nonpenetrating - mortality
title The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients
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