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The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients
Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes c...
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Published in: | PloS one 2015-09, Vol.10 (9), p.e0137127-e0137127 |
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creator | Wong, Ting Hway Nguyen, Hai V Chiu, Ming Terk Chow, Khuan Yew Ong, Marcus Eng Hock Lim, Gek Hsiang Nadkarni, Nivedita Vikas Bautista, Dianne Carrol Tan Cheng, Jolene Yu Xuan Loo, Lynette Mee Ann Seow, Dennis Chuen Chai |
description | Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients.
Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings.
Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p |
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Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings.
Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p<0.001), compared to other blunt trauma and higher fall heights. They were at higher risk of 12-month mortality (OR 1.75, 95% CI 1.18-2.58, p = 0.005), independent of ISS, RTS, age, gender, age-gender interaction and co-morbidities. Falls that were higher than 0.5m did not show this pattern. Males were at higher risk of mortality after low falls. The effect of age on mortality started at age 55 for males, and age 70 for females, and the difference was attributable to the additional mortality in male low-fallers.
The low fall mechanism can optimize prediction of long-term mortality after moderate and severe injury, and may be a surrogate marker of frailty, complementing broader-based studies on aging.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0137127</identifier><identifier>PMID: 26327646</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accidental Falls - mortality ; Adults ; Age ; Age factors ; Aged ; Aged, 80 and over ; Aging ; Biomarkers ; Body height ; Comorbidity ; Elderly patients ; Emergency medical services ; Emergency Service, Hospital ; Epidemiology ; Falls ; Female ; Females ; Fractures ; Fractures, Bone - mortality ; Frailty ; Gender differences ; Hip ; Hospital emergency services ; Humans ; Injuries ; Injury analysis ; Injury Severity Score ; Logistic Models ; Male ; Males ; Management ; Middle Aged ; Mortality ; Older people ; Patients ; Psychological aspects ; Registries ; Regression analysis ; Risk ; Sensitivity analysis ; Singapore ; Trauma ; Trauma Centers ; Wounds, Nonpenetrating - mortality</subject><ispartof>PloS one, 2015-09, Vol.10 (9), p.e0137127-e0137127</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Wong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Wong et al 2015 Wong et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-b14d130f90cb74a7e5f8007f3e020664b15d8cfd940ff7722ba629916c466dae3</citedby><cites>FETCH-LOGICAL-c692t-b14d130f90cb74a7e5f8007f3e020664b15d8cfd940ff7722ba629916c466dae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1719191753/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1719191753?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,37011,44588,53789,53791,74896</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26327646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Olivier, Jake</contributor><creatorcontrib>Wong, Ting Hway</creatorcontrib><creatorcontrib>Nguyen, Hai V</creatorcontrib><creatorcontrib>Chiu, Ming Terk</creatorcontrib><creatorcontrib>Chow, Khuan Yew</creatorcontrib><creatorcontrib>Ong, Marcus Eng Hock</creatorcontrib><creatorcontrib>Lim, Gek Hsiang</creatorcontrib><creatorcontrib>Nadkarni, Nivedita Vikas</creatorcontrib><creatorcontrib>Bautista, Dianne Carrol Tan</creatorcontrib><creatorcontrib>Cheng, Jolene Yu Xuan</creatorcontrib><creatorcontrib>Loo, Lynette Mee Ann</creatorcontrib><creatorcontrib>Seow, Dennis Chuen Chai</creatorcontrib><title>The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients.
Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings.
Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p<0.001), compared to other blunt trauma and higher fall heights. They were at higher risk of 12-month mortality (OR 1.75, 95% CI 1.18-2.58, p = 0.005), independent of ISS, RTS, age, gender, age-gender interaction and co-morbidities. Falls that were higher than 0.5m did not show this pattern. Males were at higher risk of mortality after low falls. The effect of age on mortality started at age 55 for males, and age 70 for females, and the difference was attributable to the additional mortality in male low-fallers.
The low fall mechanism can optimize prediction of long-term mortality after moderate and severe injury, and may be a surrogate marker of frailty, complementing broader-based studies on aging.</description><subject>Accidental Falls - mortality</subject><subject>Adults</subject><subject>Age</subject><subject>Age factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Biomarkers</subject><subject>Body height</subject><subject>Comorbidity</subject><subject>Elderly patients</subject><subject>Emergency medical services</subject><subject>Emergency Service, Hospital</subject><subject>Epidemiology</subject><subject>Falls</subject><subject>Female</subject><subject>Females</subject><subject>Fractures</subject><subject>Fractures, Bone - mortality</subject><subject>Frailty</subject><subject>Gender differences</subject><subject>Hip</subject><subject>Hospital emergency services</subject><subject>Humans</subject><subject>Injuries</subject><subject>Injury analysis</subject><subject>Injury Severity Score</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Males</subject><subject>Management</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Older people</subject><subject>Patients</subject><subject>Psychological aspects</subject><subject>Registries</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Sensitivity analysis</subject><subject>Singapore</subject><subject>Trauma</subject><subject>Trauma Centers</subject><subject>Wounds, Nonpenetrating - 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mortality</topic><topic>Adults</topic><topic>Age</topic><topic>Age factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Biomarkers</topic><topic>Body height</topic><topic>Comorbidity</topic><topic>Elderly patients</topic><topic>Emergency medical services</topic><topic>Emergency Service, Hospital</topic><topic>Epidemiology</topic><topic>Falls</topic><topic>Female</topic><topic>Females</topic><topic>Fractures</topic><topic>Fractures, Bone - mortality</topic><topic>Frailty</topic><topic>Gender differences</topic><topic>Hip</topic><topic>Hospital emergency services</topic><topic>Humans</topic><topic>Injuries</topic><topic>Injury analysis</topic><topic>Injury Severity Score</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Males</topic><topic>Management</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Older people</topic><topic>Patients</topic><topic>Psychological aspects</topic><topic>Registries</topic><topic>Regression analysis</topic><topic>Risk</topic><topic>Sensitivity analysis</topic><topic>Singapore</topic><topic>Trauma</topic><topic>Trauma Centers</topic><topic>Wounds, Nonpenetrating - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Ting Hway</au><au>Nguyen, Hai V</au><au>Chiu, Ming Terk</au><au>Chow, Khuan Yew</au><au>Ong, Marcus Eng Hock</au><au>Lim, Gek Hsiang</au><au>Nadkarni, Nivedita Vikas</au><au>Bautista, Dianne Carrol Tan</au><au>Cheng, Jolene Yu Xuan</au><au>Loo, Lynette Mee Ann</au><au>Seow, Dennis Chuen Chai</au><au>Olivier, Jake</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>10</volume><issue>9</issue><spage>e0137127</spage><epage>e0137127</epage><pages>e0137127-e0137127</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Frailty is associated with adverse outcomes including disability, mortality and risk of falls. Trauma registries capture a broad range of injuries. However, frail patients who fall comprise a large proportion of the injuries occurring in ageing populations and are likely to have different outcomes compared to non-frail injured patients. The effect of frail fallers on mortality is under-explored but potentially significant. Currently, many trauma registries define low falls as less than three metres, a height that is likely to include non-frailty falls. We hypothesized that the low fall from less than 0.5 metres, including same-level falls, is a surrogate marker of frailty and predicts long-term mortality in older trauma patients.
Using data from the Singapore National Trauma Registry, 2011-2013, matched till September 2014 to the death registry, we analysed adults aged over 45 admitted via the emergency department in public hospitals sustaining blunt injuries with an injury severity score (ISS) of 9 or more, excluding isolated hip fractures from same-level falls in the over 65. Patients injured by a low fall were compared to patients injured by high fall and other blunt mechanisms. Logistic regression was used to analyze 12-month mortality, controlling for mechanism of injury, ISS, revised trauma score (RTS), co-morbidities, gender, age and age-gender interaction. Different low fall height definitions, adjusting for injury regions, and analyzing the entire adult cohort were used in sensitivity analyses and did not change our findings.
Of the 8111 adults in our cohort, patients who suffered low falls were more likely to die of causes unrelated to their injuries (p<0.001), compared to other blunt trauma and higher fall heights. They were at higher risk of 12-month mortality (OR 1.75, 95% CI 1.18-2.58, p = 0.005), independent of ISS, RTS, age, gender, age-gender interaction and co-morbidities. Falls that were higher than 0.5m did not show this pattern. Males were at higher risk of mortality after low falls. The effect of age on mortality started at age 55 for males, and age 70 for females, and the difference was attributable to the additional mortality in male low-fallers.
The low fall mechanism can optimize prediction of long-term mortality after moderate and severe injury, and may be a surrogate marker of frailty, complementing broader-based studies on aging.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26327646</pmid><doi>10.1371/journal.pone.0137127</doi><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2015-09, Vol.10 (9), p.e0137127-e0137127 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_1719191753 |
source | Publicly Available Content (ProQuest); PubMed Central |
subjects | Accidental Falls - mortality Adults Age Age factors Aged Aged, 80 and over Aging Biomarkers Body height Comorbidity Elderly patients Emergency medical services Emergency Service, Hospital Epidemiology Falls Female Females Fractures Fractures, Bone - mortality Frailty Gender differences Hip Hospital emergency services Humans Injuries Injury analysis Injury Severity Score Logistic Models Male Males Management Middle Aged Mortality Older people Patients Psychological aspects Registries Regression analysis Risk Sensitivity analysis Singapore Trauma Trauma Centers Wounds, Nonpenetrating - mortality |
title | The Low Fall as a Surrogate Marker of Frailty Predicts Long-Term Mortality in Older Trauma Patients |
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