What are the Evolutionary Origins of Mitochondria? A Complex Network Approach

Mitochondria originated endosymbiotically from an Alphaproteobacteria-like ancestor. However, it is still uncertain which extant group of Alphaproteobacteria is phylogenetically closer to the mitochondrial ancestor. The proposed groups comprise the order Rickettsiales, the family Rhodospirillaceae,...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0134988-e0134988
Main Authors: Carvalho, Daniel S, Andrade, Roberto F S, Pinho, Suani T R, Góes-Neto, Aristóteles, Lobão, Thierry C P, Bomfim, Gilberto C, El-Hani, Charbel N
Format: Article
Language:English
Subjects:
Alphaproteobacteria - chemistry
Alphaproteobacteria - genetics
ATP synthase
Bacterial Proteins - chemistry
Bacterial Proteins - genetics
Biology
Datasets
Eukaryotic Cells - cytology
Eukaryotic Cells - microbiology
Evolution
Evolution (Biology)
Evolution, Molecular
Genomes
Homology
Metabolism
Mitochondria
Mitochondria - chemistry
Mitochondria - genetics
Mitochondrial Proton-Translocating ATPases - chemistry
Mitochondrial Proton-Translocating ATPases - genetics
Natural history
Origins
Phylogenetics
Phylogeny
Physics
Physiological aspects
Protein Subunits - chemistry
Protein Subunits - genetics
Proteins
Proteobacteria
Rhizobiales
Rhodobacterales
Rickettsia - chemistry
Rickettsia - genetics
Rickettsiales
Sequence Analysis, Protein
Studies
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Summary:Mitochondria originated endosymbiotically from an Alphaproteobacteria-like ancestor. However, it is still uncertain which extant group of Alphaproteobacteria is phylogenetically closer to the mitochondrial ancestor. The proposed groups comprise the order Rickettsiales, the family Rhodospirillaceae, and the genus Rickettsia. In this study, we apply a new complex network approach to investigate the evolutionary origins of mitochondria, analyzing protein sequences modules in a critical network obtained through a critical similarity threshold between the studied sequences. The dataset included three ATP synthase subunits (4, 6, and 9) and its alphaproteobacterial homologs (b, a, and c). In all the subunits, the results gave no support to the hypothesis that Rickettsiales are closely related to the mitochondrial ancestor. Our findings support the hypothesis that mitochondria share a common ancestor with a clade containing all Alphaproteobacteria orders, except Rickettsiales.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0134988