Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions

In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here w...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0137221-e0137221
Main Authors: Cao, Shannan, Liu, Peng, Zhu, Haiyan, Gong, Haiyan, Yao, Jianfeng, Sun, Yawei, Geng, Guangfeng, Wang, Tong, Feng, Sizhou, Han, Mingzhe, Zhou, Jiaxi, Xu, Yuanfu
Format: Article
Language:English
Subjects:
Acidification
Acids
Actins - genetics
Actins - immunology
Apoptosis
Apoptosis - drug effects
Apoptosis - immunology
Blood diseases
Caspase 3 - genetics
Caspase 3 - immunology
Cell death
Chemotaxis
Chemotaxis - drug effects
Chemotaxis - immunology
Endocytosis
Escherichia coli - immunology
Gene Expression Regulation
Genetic aspects
Granulocytes
Hematology
Hospitals
Humans
Hydrogen-Ion Concentration
Immune system
Immunity
Immunity, Innate
Immunology
Innate immunity
Laboratories
Leukocyte migration
N-Formylmethionine Leucyl-Phenylalanine - pharmacology
Nanoparticles
Neutrophils
Neutrophils - cytology
Neutrophils - drug effects
Neutrophils - immunology
Phagocytosis
Phagocytosis - drug effects
Phosphorylation
Physiological aspects
Physiology
Primary Cell Culture
Proto-Oncogene Proteins c-akt - genetics
Proto-Oncogene Proteins c-akt - immunology
Reactive Oxygen Species - immunology
Reactive Oxygen Species - metabolism
Respiratory burst
Respiratory Burst - drug effects
Respiratory Burst - immunology
Rodents
Signal Transduction
Stem cells
Tumors
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Description
Summary:In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0137221