Further Evidence That Cannabis Moderates Familial Correlation of Psychosis-Related Experiences

Familial correlations underlie heritability estimates of psychosis. If gene-environment interactions are important, familial correlation will vary as a function of environmental exposure. Associations between sibling and parental schizotypy (n = 669 pairs, n = 1222 observations), and between sibling...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0137625-e0137625
Main Author: van Winkel, Ruud
Format: Article
Language:English
Subjects:
Adult
Cannabis
Cannabis (Plant)
Cannabis - chemistry
Correlation
Drug abuse
Exposure
Families & family life
Family
Female
Gene expression
Gene-Environment Interaction
Heritability
Humans
Liability
Male
Marijuana
Marijuana Smoking - epidemiology
Marijuana Smoking - genetics
Medical diagnosis
Mental disorders
Mental health
Middle Aged
Parents & parenting
Patients
Pedigree
Phenotype
Physiological aspects
Population
Psychiatry
Psychosis
Psychotic disorders
Psychotic Disorders - epidemiology
Psychotic Disorders - genetics
Schizophrenia
Siblings
Studies
Urinalysis
Young Adult
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Summary:Familial correlations underlie heritability estimates of psychosis. If gene-environment interactions are important, familial correlation will vary as a function of environmental exposure. Associations between sibling and parental schizotypy (n = 669 pairs, n = 1222 observations), and between sibling schizotypy and patient CAPE psychosis (n = 978 pairs, n = 1723 observations) were examined as a function of sibling cannabis use. This design is based on the prediction that in unaffected siblings who are not exposed, vulnerability for psychosis will remain latent, whereas in case of exposure, latent psychosis vulnerability may become expressed, at the level of schizotypal symptoms, causing the phenotypic correlation between relatives to become "visible" under the influence of cannabis. Siblings exposed to recent cannabis use resembled their patient-relative more closely in terms of positive schizotypy (urinalysis(+):B = 0.30, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0137625