Stage III Colon Cancer: The Individualized Strategy of Adjuvant Chemotherapy for Aged Under and Over 70

The aim of this study was to examine the specific chemoregimens selected for adjuvant therapy in the patients with stage III colon cancer. We investigated the trends in chemotherapeutic prescribing patterns and looked for adequate therapeutic setting for these patients. 288 patients presenting with...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0138632-e0138632
Main Authors: Lu, Chieh-Sheng, Chang, Ping-Ying, Chen, Yu-Guang, Chen, Jia-Hong, Wu, Yi-Ying, Ho, Ching-Liang
Format: Article
Language:English
Subjects:
Adjuvant chemotherapy
Adult
Age Factors
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer
Cancer therapies
Carcinoembryonic antigen
Care and treatment
Chemotherapy
Chemotherapy, Adjuvant
Colon
Colon cancer
Colonic Neoplasms - drug therapy
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Colonic Neoplasms - surgery
Colonoscopy
Colorectal cancer
Combined Modality Therapy
Confidence intervals
Demographic aspects
Demographics
Female
Fluorouracil - therapeutic use
Hematology
Hospitals
Humans
Internal medicine
Intravenous administration
Leucovorin - therapeutic use
Lymphatic system
Male
Medical prognosis
Medical records
Medical screening
Medicine
Middle Aged
Neoplasm Staging
Oncology
Organoplatinum Compounds - therapeutic use
Oxaliplatin
Patients
Precision Medicine
Prognosis
Retrospective Studies
Statistical analysis
Surgery
Surveillance
Survival
Systematic review
Tegafur
Tegafur - therapeutic use
Tumors
Uracil
Womens health
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Summary:The aim of this study was to examine the specific chemoregimens selected for adjuvant therapy in the patients with stage III colon cancer. We investigated the trends in chemotherapeutic prescribing patterns and looked for adequate therapeutic setting for these patients. 288 patients presenting with stage III colon cancer and undergoing adjuvant therapies after curative surgery for more than 3-month were enrolled between January 2006 and December 2011. Demographic characteristics and therapeutic factors were analyzed, including age, gender, histological grade, tumor sizes, tumor location, pathologic stage, performance status, serum carcinoembryonic antigen, regimens selection, interval from the operation to the start of adjuvant therapy and prolonged adjuvant therapy. Kaplan- Meier methods were utilized for drawing survival curves and Cox model was used to analyze survival, prognostic factors. The analysis showed that the patients aged under 70 received more intensive therapies than those aged over 70 (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0138632