Efficacy and Safety of an Everolimus- vs. a Mycophenolate Mofetil-Based Regimen in Pediatric Renal Transplant Recipients

Data on the efficacy and safety of everolimus in pediatric renal transplantation compared to other immunosuppressive regimens are scarce. We therefore performed a multicenter, observational, matched cohort study over 4 years post-transplant in 35 patients on everolimus plus low-dose cyclosporine, wh...

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Bibliographic Details
Published in:PloS one 2015-09, Vol.10 (9), p.e0135439-e0135439
Main Authors: Brunkhorst, Lena Caroline, Fichtner, Alexander, Höcker, Britta, Burmeister, Greta, Ahlenstiel-Grunow, Thurid, Krupka, Kai, Bald, Martin, Zapf, Antonia, Tönshoff, Burkhard, Pape, Lars
Format: Article
Language:English
Subjects:
Adolescent
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antibodies
Biomarkers
Biopsy
Calcineurin
Child
Child, Preschool
Children
Children & youth
Cohort Studies
Corticoids
Corticosteroids
Cyclosporins
Cytomegalovirus
Drug Therapy, Combination
Epidermal growth factor receptors
Everolimus - administration & dosage
Everolimus - adverse effects
Female
Graft rejection
Graft Rejection - drug therapy
Graft Rejection - immunology
Graft Survival - drug effects
Graft Survival - immunology
Health risk assessment
Histocompatibility antigen HLA
HLA Antigens - immunology
Hospitalization
Hospitals
Humans
Hyperlipidemia
Hypertension
Immunosuppressive agents
Immunosuppressive Agents - administration & dosage
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Inhibitor drugs
Isoantibodies - immunology
Kidney Function Tests
Kidney transplantation
Kidney Transplantation - adverse effects
Male
Medical schools
Mycophenolate mofetil
Mycophenolic acid
Mycophenolic Acid - administration & dosage
Mycophenolic Acid - adverse effects
Mycophenolic Acid - analogs & derivatives
Mycophenolic Acid - therapeutic use
Nephrology
Opportunistic Infections - etiology
Patients
Pediatrics
Retrospective Studies
Safety
Systematic review
Tissue Donors
Transplant Recipients
Transplantation
Transplants & implants
Treatment Outcome
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Summary:Data on the efficacy and safety of everolimus in pediatric renal transplantation compared to other immunosuppressive regimens are scarce. We therefore performed a multicenter, observational, matched cohort study over 4 years post-transplant in 35 patients on everolimus plus low-dose cyclosporine, who were matched (1:2) with a control group of 70 children receiving a standard-dose calcineurin-inhibitor- and mycophenolate mofetil-based regimen. Corticosteroids were withdrawn in 83% in the everolimus vs. 39% in the control group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0135439