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Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries
Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed...
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Published in: | PloS one 2015-09, Vol.10 (9), p.e0139413-e0139413 |
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description | Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.
A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.
Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.
We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories. |
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A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.
Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.
We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0139413</identifier><identifier>PMID: 26418860</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Alleles ; Archives & records ; Biomedical research ; Bipolar disorder ; Bipolar Disorder - diagnosis ; Bipolar Disorder - genetics ; Brain research ; Chromosome 15 ; Chromosomes ; Diagnosis ; Diagnostic systems ; Family studies ; Gene Frequency ; Genes ; Genetic aspects ; Genetic Predisposition to Disease - genetics ; Genome-wide association studies ; Genomes ; Genotype ; Haplotypes ; Humans ; Logistic Models ; Medical diagnosis ; Medicine ; Mental disorders ; Middle Aged ; Patients ; Phenotype ; Phenotypes ; Physiological aspects ; Polymorphism, Single Nucleotide ; Psychiatry ; Regression analysis ; Risk Factors ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - genetics ; Sialyltransferases - genetics ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Studies ; Young Adult</subject><ispartof>PloS one, 2015-09, Vol.10 (9), p.e0139413-e0139413</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Yang et al 2015 Yang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-d35eb20df338230156f307340911aa4f374a97c69f220663d03bd8c107b66aa43</citedby><cites>FETCH-LOGICAL-c758t-d35eb20df338230156f307340911aa4f374a97c69f220663d03bd8c107b66aa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1719322275/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1719322275?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26418860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bardoni, Barbara</contributor><creatorcontrib>Yang, So Yung</creatorcontrib><creatorcontrib>Huh, Ik Soo</creatorcontrib><creatorcontrib>Baek, Ji Hyun</creatorcontrib><creatorcontrib>Cho, Eun-Young</creatorcontrib><creatorcontrib>Choi, Mi Ji</creatorcontrib><creatorcontrib>Ryu, Seunghyong</creatorcontrib><creatorcontrib>Kim, Ji Sun</creatorcontrib><creatorcontrib>Park, Taesung</creatorcontrib><creatorcontrib>Ha, Kyooseob</creatorcontrib><creatorcontrib>Hong, Kyung Sue</creatorcontrib><title>Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.
A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.
Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.
We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.</description><subject>Adult</subject><subject>Alleles</subject><subject>Archives & records</subject><subject>Biomedical research</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - genetics</subject><subject>Brain research</subject><subject>Chromosome 15</subject><subject>Chromosomes</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Family studies</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Medical diagnosis</subject><subject>Medicine</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Physiological aspects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Psychiatry</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - genetics</subject><subject>Sialyltransferases - genetics</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Studies</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk0tv1DAQxyMEomXhGyCIhITgsIvtSez4grQtr0iVKnULV8tJnI2XrL21E16fHmc3rTaoB-SDX7_5z3g8E0XPMVpgYPjdxvbOyHaxs0YtEAaeYHgQnWIOZE4JgodH65PoifcbhFLIKH0cnRCa4Cyj6DTaLr23pZadtiYuVPdTKROvrrNVviSxNFXcNSq-0v57bOt4VTb6j901Thkt97dnemdb6eI8_qC9dZVysSyd9T7s5dpY3-kyPrO9qaTTyj-NHtWy9erZOM-ir58-Xp9_mV9cfs7PlxfzkqVZN68gVQVBVQ2QEUA4pTUgBgniGEuZ1MASyVlJeU0IohQqBEWVlRixgtIAwCx6edDdtdaLMVNeYDZkhBCWBiI_EJWVG7Fzeivdb2GlFvsD69ZCuhB8qwQjheI4I1imSZIBcJQplDJOeJryKvieRe9Hb32xVVWpTOdkOxGd3hjdiLX9IZI0Y5ziIPBmFHD2ple-E1vtS9W20ijb7-MOfjHAEPerf9D7XzdSaxkeoE1tg99yEBXLBBCBlAEL1OIeKoxKbXUZyqrW4Xxi8HZiEJhO_erWsvde5Kur_2cvv03Z10dso2TbNd62_VCUfgomB3BfY07Vd0nGSAxdcZsNMXSFGLsimL04_qA7o9s2gL8xlQRN</recordid><startdate>20150929</startdate><enddate>20150929</enddate><creator>Yang, So Yung</creator><creator>Huh, Ik Soo</creator><creator>Baek, Ji Hyun</creator><creator>Cho, Eun-Young</creator><creator>Choi, Mi Ji</creator><creator>Ryu, Seunghyong</creator><creator>Kim, Ji Sun</creator><creator>Park, Taesung</creator><creator>Ha, Kyooseob</creator><creator>Hong, Kyung Sue</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20150929</creationdate><title>Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries</title><author>Yang, So Yung ; Huh, Ik Soo ; Baek, Ji Hyun ; Cho, Eun-Young ; Choi, Mi Ji ; Ryu, Seunghyong ; Kim, Ji Sun ; Park, Taesung ; Ha, Kyooseob ; Hong, Kyung Sue</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-d35eb20df338230156f307340911aa4f374a97c69f220663d03bd8c107b66aa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Archives & records</topic><topic>Biomedical research</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - genetics</topic><topic>Brain research</topic><topic>Chromosome 15</topic><topic>Chromosomes</topic><topic>Diagnosis</topic><topic>Diagnostic systems</topic><topic>Family studies</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Medical diagnosis</topic><topic>Medicine</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Physiological aspects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Psychiatry</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - genetics</topic><topic>Sialyltransferases - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, So Yung</au><au>Huh, Ik Soo</au><au>Baek, Ji Hyun</au><au>Cho, Eun-Young</au><au>Choi, Mi Ji</au><au>Ryu, Seunghyong</au><au>Kim, Ji Sun</au><au>Park, Taesung</au><au>Ha, Kyooseob</au><au>Hong, Kyung Sue</au><au>Bardoni, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-09-29</date><risdate>2015</risdate><volume>10</volume><issue>9</issue><spage>e0139413</spage><epage>e0139413</epage><pages>e0139413-e0139413</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Findings from family studies and recent genome-wide association studies have indicated overlap in the risk genes between schizophrenia and bipolar disorder (BD). After finding a linkage between the ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sicalyltransferase 2 gene) locus (15q26) and mixed families with schizophrenia and BD, several studies have reported a significant association between this gene and schizophrenia or BD. We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.
A total of 582 patients with schizophrenia, 339 patients with BD, and 502 healthy controls were included. Thirty-one tag single nucleotide polymorphisms (SNPs) across the ST8SIA2 region and three other SNPs showing significant associations in previous studies were genotyped. The associations were evaluated by logistic regression analysis using additive, dominant, and recessive genetic models.
Fourteen of 34 SNPs showed a nominally significant association (p < 0.05) with at least one diagnostic group. These association trends were strongest for the schizophrenia and combined schizophrenia and bipolar I disorder (BD-I) groups. The strongest association was observed in rs11637898 for schizophrenia (p = 0.0033) and BD-I (p = 0.0050) under the dominant model. The association between rs11637898 and the combined schizophrenia and BD-I group (p = 0.0006, under the dominant model) remained significant after correcting for multiple testing.
We identified a possible role of ST8SIA2 in the common susceptibility of schizophrenia and BD-I. However, no association trend was observed for bipolar II disorder. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26418860</pmid><doi>10.1371/journal.pone.0139413</doi><oa>free_for_read</oa></addata></record> |
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subjects | Adult Alleles Archives & records Biomedical research Bipolar disorder Bipolar Disorder - diagnosis Bipolar Disorder - genetics Brain research Chromosome 15 Chromosomes Diagnosis Diagnostic systems Family studies Gene Frequency Genes Genetic aspects Genetic Predisposition to Disease - genetics Genome-wide association studies Genomes Genotype Haplotypes Humans Logistic Models Medical diagnosis Medicine Mental disorders Middle Aged Patients Phenotype Phenotypes Physiological aspects Polymorphism, Single Nucleotide Psychiatry Regression analysis Risk Factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Sialyltransferases - genetics Single nucleotide polymorphisms Single-nucleotide polymorphism Studies Young Adult |
title | Association between ST8SIA2 and the Risk of Schizophrenia and Bipolar I Disorder across Diagnostic Boundaries |
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