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Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models
Interleukin (IL)-20 is a proinflammatory cytokine in the IL-10 family. IL-20 is associated with tumor promotion in the pathogenesis of oral, bladder, and breast cancer. However, little is known about the role of IL-20 in prostate cancer. We hypothesize that IL-20 promotes the growth of prostate canc...
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| Published in: | PloS one 2015-10, Vol.10 (10), p.e0139871-e0139871 |
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| description | Interleukin (IL)-20 is a proinflammatory cytokine in the IL-10 family. IL-20 is associated with tumor promotion in the pathogenesis of oral, bladder, and breast cancer. However, little is known about the role of IL-20 in prostate cancer. We hypothesize that IL-20 promotes the growth of prostate cancer cells. Immunohistochemical staining showed that IL-20 and its receptors were expressed in human PC-3 and LNCaP prostate cancer cell lines and in prostate tumor tissue from 40 patients. In vitro, IL-20 upregulated N-cadherin, STAT3, vimentin, fibronectin, RANKL, cathepsin G, and cathepsin K, and increased the migration and colony formation of prostate cancer cells via activated p38, ERK1/2, AKT, and NF-κB signals in PC-3 cells. We investigated the effects of anti-IL-20 monoclonal antibody 7E on prostate tumor growth in vivo using SCID mouse subcutaneous and intratibial xenograft tumor models. In vivo, 7E reduced tumor growth, suppressed tumor-mediated osteolysis, and protected bone mineral density after intratibial injection of prostate cancer cells. We conclude that IL-20 is involved in the cell migration, colony formation, and tumor-induced osteolysis of prostate cancer. Therefore, IL-20 might be a novel target for treating prostate cancer. |
| doi_str_mv | 10.1371/journal.pone.0139871 |
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IL-20 is associated with tumor promotion in the pathogenesis of oral, bladder, and breast cancer. However, little is known about the role of IL-20 in prostate cancer. We hypothesize that IL-20 promotes the growth of prostate cancer cells. Immunohistochemical staining showed that IL-20 and its receptors were expressed in human PC-3 and LNCaP prostate cancer cell lines and in prostate tumor tissue from 40 patients. In vitro, IL-20 upregulated N-cadherin, STAT3, vimentin, fibronectin, RANKL, cathepsin G, and cathepsin K, and increased the migration and colony formation of prostate cancer cells via activated p38, ERK1/2, AKT, and NF-κB signals in PC-3 cells. We investigated the effects of anti-IL-20 monoclonal antibody 7E on prostate tumor growth in vivo using SCID mouse subcutaneous and intratibial xenograft tumor models. In vivo, 7E reduced tumor growth, suppressed tumor-mediated osteolysis, and protected bone mineral density after intratibial injection of prostate cancer cells. We conclude that IL-20 is involved in the cell migration, colony formation, and tumor-induced osteolysis of prostate cancer. Therefore, IL-20 might be a novel target for treating prostate cancer.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0139871</identifier><identifier>PMID: 26440411</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>AKT protein ; Analysis ; Anesthesiology ; Animal models ; Animals ; Antibodies, Monoclonal - pharmacology ; Antibodies, Monoclonal - therapeutic use ; Biochemistry ; Biocompatibility ; Biomedical materials ; Bladder ; Bone cancer ; Bone density ; Bone growth ; Bone mineral density ; Breast cancer ; Cadherins ; Cancer ; Cathepsin G ; Cathepsin K ; Cell adhesion & migration ; Cell growth ; Cell Line, Tumor ; Cell migration ; Cell Movement - drug effects ; Colonies ; Cytokines ; Disease Models, Animal ; Drug therapy ; Fibronectin ; Gene expression ; Genetic aspects ; Growth ; Growth factors ; Humans ; Inflammation ; Interleukin 20 ; Interleukins ; Interleukins - immunology ; Kinases ; Male ; Medicine ; Metastasis ; Mice ; Molecular biology ; Monoclonal antibodies ; N-Cadherin ; NF-κB protein ; Osteolysis ; Osteolysis - drug therapy ; Osteolysis - immunology ; Osteolysis - pathology ; Pathogenesis ; Physiological aspects ; Prostate cancer ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - immunology ; Prostatic Neoplasms - pathology ; Protein expression ; Receptors ; Receptors, Interleukin - metabolism ; Signal Transduction ; Tumor cell lines ; Tumors ; Up-Regulation - drug effects ; Xenografts ; Xenotransplantation</subject><ispartof>PloS one, 2015-10, Vol.10 (10), p.e0139871-e0139871</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Hsu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Hsu et al 2015 Hsu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c718t-65934e908b9ea8f2a1882c37e8c5e1b3e9cfb4655865f59657eb6fa6b629a5743</citedby><cites>FETCH-LOGICAL-c718t-65934e908b9ea8f2a1882c37e8c5e1b3e9cfb4655865f59657eb6fa6b629a5743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1719376249/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1719376249?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26440411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Heymann, Dominique</contributor><creatorcontrib>Hsu, Yu-Hsiang</creatorcontrib><creatorcontrib>Wu, Cheng-Ying</creatorcontrib><creatorcontrib>Hsing, Chung-Hsi</creatorcontrib><creatorcontrib>Lai, Wei-Ting</creatorcontrib><creatorcontrib>Wu, Li-Wha</creatorcontrib><creatorcontrib>Chang, Ming-Shi</creatorcontrib><title>Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interleukin (IL)-20 is a proinflammatory cytokine in the IL-10 family. IL-20 is associated with tumor promotion in the pathogenesis of oral, bladder, and breast cancer. However, little is known about the role of IL-20 in prostate cancer. We hypothesize that IL-20 promotes the growth of prostate cancer cells. Immunohistochemical staining showed that IL-20 and its receptors were expressed in human PC-3 and LNCaP prostate cancer cell lines and in prostate tumor tissue from 40 patients. In vitro, IL-20 upregulated N-cadherin, STAT3, vimentin, fibronectin, RANKL, cathepsin G, and cathepsin K, and increased the migration and colony formation of prostate cancer cells via activated p38, ERK1/2, AKT, and NF-κB signals in PC-3 cells. We investigated the effects of anti-IL-20 monoclonal antibody 7E on prostate tumor growth in vivo using SCID mouse subcutaneous and intratibial xenograft tumor models. In vivo, 7E reduced tumor growth, suppressed tumor-mediated osteolysis, and protected bone mineral density after intratibial injection of prostate cancer cells. We conclude that IL-20 is involved in the cell migration, colony formation, and tumor-induced osteolysis of prostate cancer. Therefore, IL-20 might be a novel target for treating prostate cancer.</description><subject>AKT protein</subject><subject>Analysis</subject><subject>Anesthesiology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Biochemistry</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bladder</subject><subject>Bone cancer</subject><subject>Bone density</subject><subject>Bone growth</subject><subject>Bone mineral density</subject><subject>Breast cancer</subject><subject>Cadherins</subject><subject>Cancer</subject><subject>Cathepsin G</subject><subject>Cathepsin K</subject><subject>Cell adhesion & migration</subject><subject>Cell growth</subject><subject>Cell Line, Tumor</subject><subject>Cell migration</subject><subject>Cell Movement - drug effects</subject><subject>Colonies</subject><subject>Cytokines</subject><subject>Disease Models, Animal</subject><subject>Drug therapy</subject><subject>Fibronectin</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Growth</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Interleukin 20</subject><subject>Interleukins</subject><subject>Interleukins - immunology</subject><subject>Kinases</subject><subject>Male</subject><subject>Medicine</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Molecular biology</subject><subject>Monoclonal antibodies</subject><subject>N-Cadherin</subject><subject>NF-κB protein</subject><subject>Osteolysis</subject><subject>Osteolysis - drug therapy</subject><subject>Osteolysis - immunology</subject><subject>Osteolysis - pathology</subject><subject>Pathogenesis</subject><subject>Physiological aspects</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - immunology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Protein expression</subject><subject>Receptors</subject><subject>Receptors, Interleukin - metabolism</subject><subject>Signal Transduction</subject><subject>Tumor cell lines</subject><subject>Tumors</subject><subject>Up-Regulation - drug effects</subject><subject>Xenografts</subject><subject>Xenotransplantation</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk02P0zAQhiMEYpeFf4AgEhKCQ0ocf8S-IJUKlkqtiljgajnOpPUqjYvtAP33uNvsqkF7QD7Emjzzzvi1J0meo3yCcIneXdvedaqd7GwHkxxhwUv0IDlHAhcZK3L88GR_ljzx_jrPKeaMPU7OCkZIThA6T2DaBZPNF1mRp0vbWd3aKJoeopWt9-lVv9s58B58-sVZH1SAdKY6DS69dPZ32KSqq9MPsYd05QPYdu-NT02XLntnYnBpa2j90-RRo1oPz4bvRfL908dvs8_ZYnU5n00XmS4RDxmjAhMQOa8EKN4UCnFeaFwC1xRQhUHopiKMUs5oQwWjJVSsUaxihVC0JPgieXnU3bXWy8EhL1EZnShZQUQk5keitupa7pzZKreXVhl5E7BuLZULRrcgEW84q0h0jVDCG1zF8hSDQlqJhrAiar0fqvXVFmoNXXCqHYmO_3RmI9f2lyRUEFEc2n0zCDj7swcf5NZ4DW2rOrD9oe8iJxSRm75f_YPef7qBWqt4ANM1NtbVB1E5JTjnRCDEIjW5h4qrhq3R8SobE-OjhLejhMgE-BPWqvdezq--_j-7-jFmX5-wG1Bt2Hjb9sHYzo9BcgR1fIPeQXNnMsrlYRpu3ZCHaZDDNMS0F6cXdJd0-_zxX9iwA0o</recordid><startdate>20151006</startdate><enddate>20151006</enddate><creator>Hsu, Yu-Hsiang</creator><creator>Wu, Cheng-Ying</creator><creator>Hsing, Chung-Hsi</creator><creator>Lai, Wei-Ting</creator><creator>Wu, Li-Wha</creator><creator>Chang, Ming-Shi</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20151006</creationdate><title>Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models</title><author>Hsu, Yu-Hsiang ; Wu, Cheng-Ying ; Hsing, Chung-Hsi ; Lai, Wei-Ting ; Wu, Li-Wha ; Chang, Ming-Shi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c718t-65934e908b9ea8f2a1882c37e8c5e1b3e9cfb4655865f59657eb6fa6b629a5743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>AKT protein</topic><topic>Analysis</topic><topic>Anesthesiology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Antibodies, Monoclonal - pharmacology</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Biochemistry</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Bladder</topic><topic>Bone cancer</topic><topic>Bone density</topic><topic>Bone growth</topic><topic>Bone mineral density</topic><topic>Breast cancer</topic><topic>Cadherins</topic><topic>Cancer</topic><topic>Cathepsin G</topic><topic>Cathepsin K</topic><topic>Cell adhesion & migration</topic><topic>Cell growth</topic><topic>Cell Line, Tumor</topic><topic>Cell migration</topic><topic>Cell Movement - drug effects</topic><topic>Colonies</topic><topic>Cytokines</topic><topic>Disease Models, Animal</topic><topic>Drug therapy</topic><topic>Fibronectin</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Growth</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Interleukin 20</topic><topic>Interleukins</topic><topic>Interleukins - immunology</topic><topic>Kinases</topic><topic>Male</topic><topic>Medicine</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Molecular biology</topic><topic>Monoclonal antibodies</topic><topic>N-Cadherin</topic><topic>NF-κB protein</topic><topic>Osteolysis</topic><topic>Osteolysis - drug therapy</topic><topic>Osteolysis - immunology</topic><topic>Osteolysis - pathology</topic><topic>Pathogenesis</topic><topic>Physiological aspects</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - immunology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Protein expression</topic><topic>Receptors</topic><topic>Receptors, Interleukin - metabolism</topic><topic>Signal Transduction</topic><topic>Tumor cell lines</topic><topic>Tumors</topic><topic>Up-Regulation - drug effects</topic><topic>Xenografts</topic><topic>Xenotransplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsu, Yu-Hsiang</creatorcontrib><creatorcontrib>Wu, Cheng-Ying</creatorcontrib><creatorcontrib>Hsing, Chung-Hsi</creatorcontrib><creatorcontrib>Lai, Wei-Ting</creatorcontrib><creatorcontrib>Wu, Li-Wha</creatorcontrib><creatorcontrib>Chang, Ming-Shi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints in Context (Gale)</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsu, Yu-Hsiang</au><au>Wu, Cheng-Ying</au><au>Hsing, Chung-Hsi</au><au>Lai, Wei-Ting</au><au>Wu, Li-Wha</au><au>Chang, Ming-Shi</au><au>Heymann, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-10-06</date><risdate>2015</risdate><volume>10</volume><issue>10</issue><spage>e0139871</spage><epage>e0139871</epage><pages>e0139871-e0139871</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interleukin (IL)-20 is a proinflammatory cytokine in the IL-10 family. IL-20 is associated with tumor promotion in the pathogenesis of oral, bladder, and breast cancer. However, little is known about the role of IL-20 in prostate cancer. We hypothesize that IL-20 promotes the growth of prostate cancer cells. Immunohistochemical staining showed that IL-20 and its receptors were expressed in human PC-3 and LNCaP prostate cancer cell lines and in prostate tumor tissue from 40 patients. In vitro, IL-20 upregulated N-cadherin, STAT3, vimentin, fibronectin, RANKL, cathepsin G, and cathepsin K, and increased the migration and colony formation of prostate cancer cells via activated p38, ERK1/2, AKT, and NF-κB signals in PC-3 cells. We investigated the effects of anti-IL-20 monoclonal antibody 7E on prostate tumor growth in vivo using SCID mouse subcutaneous and intratibial xenograft tumor models. In vivo, 7E reduced tumor growth, suppressed tumor-mediated osteolysis, and protected bone mineral density after intratibial injection of prostate cancer cells. We conclude that IL-20 is involved in the cell migration, colony formation, and tumor-induced osteolysis of prostate cancer. Therefore, IL-20 might be a novel target for treating prostate cancer.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26440411</pmid><doi>10.1371/journal.pone.0139871</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-10, Vol.10 (10), p.e0139871-e0139871 |
| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | AKT protein Analysis Anesthesiology Animal models Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Biochemistry Biocompatibility Biomedical materials Bladder Bone cancer Bone density Bone growth Bone mineral density Breast cancer Cadherins Cancer Cathepsin G Cathepsin K Cell adhesion & migration Cell growth Cell Line, Tumor Cell migration Cell Movement - drug effects Colonies Cytokines Disease Models, Animal Drug therapy Fibronectin Gene expression Genetic aspects Growth Growth factors Humans Inflammation Interleukin 20 Interleukins Interleukins - immunology Kinases Male Medicine Metastasis Mice Molecular biology Monoclonal antibodies N-Cadherin NF-κB protein Osteolysis Osteolysis - drug therapy Osteolysis - immunology Osteolysis - pathology Pathogenesis Physiological aspects Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Protein expression Receptors Receptors, Interleukin - metabolism Signal Transduction Tumor cell lines Tumors Up-Regulation - drug effects Xenografts Xenotransplantation |
| title | Anti-IL-20 Monoclonal Antibody Suppresses Prostate Cancer Growth and Bone Osteolysis in Murine Models |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T08%3A42%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anti-IL-20%20Monoclonal%20Antibody%20Suppresses%20Prostate%20Cancer%20Growth%20and%20Bone%20Osteolysis%20in%20Murine%20Models&rft.jtitle=PloS%20one&rft.au=Hsu,%20Yu-Hsiang&rft.date=2015-10-06&rft.volume=10&rft.issue=10&rft.spage=e0139871&rft.epage=e0139871&rft.pages=e0139871-e0139871&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0139871&rft_dat=%3Cgale_plos_%3EA430849116%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c718t-65934e908b9ea8f2a1882c37e8c5e1b3e9cfb4655865f59657eb6fa6b629a5743%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1719376249&rft_id=info:pmid/26440411&rft_galeid=A430849116&rfr_iscdi=true |