National Trend and Characteristics of Acute Hepatitis C among HIV-Infected Individuals: A Matched Case-Control Study-Taiwan, 2001-2014

• Published in: PloS one 2015-10, Vol.10 (10), p.e0139687-e0139687
• Main Authors: Lo, Yi-Chun, Tsai, Mao-Song, Sun, Hsin-Yun, Hung, Chien-Ching, Chuang, Jen-Hsiang
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; Case-Control Studies; Comorbidity; Complications and side effects; Confidence intervals; Demographic aspects; Diagnosis; Disease control; Disease transmission; Genotypes; Gonorrhea; Health aspects; Health care facilities; Health risk assessment; Hepatitis; Hepatitis C; Hepatitis C - epidemiology; Hepatitis C virus; HIV; HIV infections; HIV Infections - epidemiology; Homosexuality, Male; Human immunodeficiency virus; Humans; Incidence; Male; Males; Medical diagnosis; Men; Metropolitan areas; Middle Aged; Patients; Population Surveillance; Prevalence; Risk Factors; Sex; Sexually transmitted diseases; Statistical analysis; STD; Surveillance; Syphilis; Taiwan - epidemiology; Unsafe Sex; Viruses; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0139687

Hepatitis C virus (HCV) infection has been increasingly recognized among HIV-infected men who have sex with men (MSM) worldwide. We investigated the trend of and factors associated with acute hepatitis C (AHC) among HIV-infected individuals in Taiwan. The National Disease Surveillance System collects characteristics of AHC, HIV, syphilis, and gonorrhea cases through mandatory reports and patient interviews. Reported AHC patients in 2014 were interviewed additionally on sexual and parenteral exposures. Information on HCV genotypes were collected from the largest medical center serving HIV-infected Taiwanese. We defined an HIV/AHC case as a documented negative HCV antibody test result followed within 12 months by a positive test in a previously reported HIV-infected individual. Each case was matched to two HIV-infected, non-AHC controls for age, age of HIV diagnosis, sex, transmission route, HIV diagnosis date, and county/city. Conditional logistic regression was used to identify associated characteristics. During 2001-2014, 93 of 6,624 AHC reports were HIV/AHC cases; the annual case count increased from one in 2009 to 34 in 2014. All were males (81 [87%] MSM) aged 21-49 years with AHC diagnosed 2-5,923 days after HIV diagnoses. Sixty-eight (73%) lived in the Taipei metropolitan area. Detected HCV genotypes were 2a (n = 6), 1b (n = 5), 1b + 2a (n = 1) and 2b (n = 1). Among 28 HIV/AHC patients interviewed in 2014, 13 (46%) reported engaging in unprotected sex ≤3 months before AHC diagnosis. Seventy-nine HIV/AHC cases were matched to 158 controls. HIV/AHC was associated with recent syphilis (adjusted odds ratio [aOR], 10.9; 95% confidence interval [CI], 4.2-28.6) and last syphilis >6 months (aOR, 2.9; 95% CI, 1.2-6.9). HIV/AHC cases continued to increase particularly among sexually active HIV-infected MSM with a syphilis diagnosis in northern Taiwan. We recommend surveillance of associated behavioral and virologic characteristics and HCV counseling and testing for HIV-infected men in Taiwan.