New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients

Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2015-09, Vol.9 (9), p.e0004030-e0004030
Main Authors: Papotto, Pedro Henrique, Maeda, Solange, Tomimori, Jane, Xavier, Marília Brasil, Rizzo, Luiz Vicente, Kallas, Esper Georges, Carvalho, Karina Inácio
Format: Article
Language:English
Subjects:
Adult
Asthma
Bacterial infections
Coinfection - immunology
Cytokines
Development and progression
Female
HIV
HIV infection
HIV Infections - complications
HIV Infections - immunology
HIV Infections - virology
HIV-1 - immunology
Human immunodeficiency virus
Human immunodeficiency virus 1
Humans
Immune response
Immune system
Immunity, Innate
Immunology
Infections
Infectious diseases
Leprosy
Leprosy - complications
Leprosy - immunology
Leprosy - microbiology
Lymphocyte Subsets - immunology
Male
Medical research
Medicine, Experimental
Middle Aged
Mycobacterium leprae
Mycobacterium leprae - immunology
Physiological aspects
Regulation
Skin
Viral infections
Young Adult
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Summary:Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0004030