IL-10 Gene Polymorphisms Are Associated with Post-Bronchiolitis Lung Function Abnormalities at Six Years of Age

• Published in: PloS one 2015-10, Vol.10 (10), p.e0140799-e0140799
• Main Authors: Lauhkonen, Eero, Koponen, Petri, Teräsjärvi, Johanna, Gröndahl-Yli-Hannuksela, Kirsi, Vuononvirta, Juho, Nuolivirta, Kirsi, Toikka, Jyri O, Helminen, Merja, He, Qiushui, Korppi, Matti
• Format: Article
• Language: English
• Subjects: Abnormalities; Age; Analysis; Asthma; Bronchiolitis; Bronchiolitis - genetics; Bronchiolitis - metabolism; Bronchiolitis - pathology; Bronchiolitis - physiopathology; Bronchopneumonia; Care and treatment; Child; Child, Preschool; Children; Children & youth; Childrens health; Cytokines; Female; Genetic aspects; Genetic diversity; Genetic polymorphisms; Genomes; Genotypes; Haplotypes; Hospitals; Humans; Immunology; Infant; Infectious diseases; Interleukin; Interleukin 1; Interleukin 10; Interleukin-10 - genetics; Interleukin-10 - metabolism; Life assessment; Lung - metabolism; Lung - pathology; Lung - physiopathology; Lungs; Male; Medical research; Patients; Physiology; Polymorphism, Single Nucleotide; Pregnancy; Preschool children; Prospective Studies; Reactance; Respiratory function; Respiratory Function Tests; Respiratory syncytial virus; Respiratory tract; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Wheezing
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0140799

Interleukin-10 (IL-10) has been associated with wheezing and asthma in children and the genetic variation of the IL-10 cytokine production may be linked to post-bronchiolitis lung function. We used impulse oscillometry (IOS) to evaluate the associations of IL10 polymorphisms with lung function at a median age of 6.3 years in children hospitalised for bronchiolitis before six months of age. We performed baseline and post-exercise IOS on 103 former bronchiolitis patients. Data on single nucleotide polymorphisms (SNP) of IL10 rs1800896 (-1082G/A), rs1800871 (-819C/T), rs1800872 (-592C/A) were available for 99 children and of IL10 rs1800890 (-3575T/A) for 98 children. IL10 rs1800896, rs1800871 and rs1800872 combined genotype AA+CT+CA and carriage of haplotype ATA, respectively, were associated with higher resistance and lower reactance in baseline IOS in adjusted analyses. At IL10 rs1800890, the A/A-genotype and carriers of A-allele were associated with lower reactance in baseline IOS. There were no significant associations between the studied SNPs and airway hyper-reactivity to exercise. Low-IL-10-producing polymorphisms in the IL-10 encoding gene were associated with obstructive lung function parameters, suggesting an important role for IL-10 in development of lung function deficit in early bronchiolitis patients.