The Relationship between Corvis ST Tonometry Measured Corneal Parameters and Intraocular Pressure, Corneal Thickness and Corneal Curvature

• Published in: PloS one 2015-10, Vol.10 (10), p.e0140385-e0140385
• Main Authors: Asaoka, Ryo, Nakakura, Shunsuke, Tabuchi, Hitoshi, Murata, Hiroshi, Nakao, Yoshitaka, Ihara, Noriko, Rimayanti, Ulfah, Aihara, Makoto, Kiuchi, Yoshiaki
• Format: Article
• Language: English
• Subjects: Adult; Age; Age Factors; Aged; Aged, 80 and over; Biomechanics; Cataracts; Concavity; Cornea; Cornea - physiology; Correlation analysis; Curvature; Deformation; Deformation mechanisms; Disease; Elasticity; Eye (anatomy); Female; Glaucoma; Hospitals; Humans; Hypothesis testing; Intraocular pressure; Intraocular Pressure - physiology; Linear Models; Male; Mathematical models; Middle Aged; Modelling; Multivariate Analysis; Parameters; Physiological aspects; Pressure; Prospective Studies; Science; Sinapis; Studies; Tonometry, Ocular - methods; Velocity; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0140385

The purpose of the study was to investigate the correlation between Corneal Visualization Scheimpflug Technology (Corvis ST tonometry: CST) parameters and various other ocular parameters, including intraocular pressure (IOP) with Goldmann applanation tonometry. IOP with Goldmann applanation tonometry (IOP-G), central corneal thickness (CCT), axial length (AL), corneal curvature, and CST parameters were measured in 94 eyes of 94 normal subjects. The relationship between ten CST parameters against age, gender, IOP-G, AL, CST-determined CCT and average corneal curvature was investigated using linear modeling. In addition, the relationship between IOP-G versus CST-determined CCT, AL, and other CST parameters was also investigated using linear modeling. Linear modeling showed that the CST measurement 'A time-1' is dependent on IOP-G, age, AL, and average corneal curvature; 'A length-1' depends on age and average corneal curvature; 'A velocity-1' depends on IOP-G and AL; 'A time-2' depends on IOP-G, age, and AL; 'A length-2' depends on CCT; 'A velocity-2' depends on IOP-G, age, AL, CCT, and average corneal curvature; 'peak distance' depends on gender; 'maximum deformation amplitude' depends on IOP-G, age, and AL. In the optimal model for IOP-G, A time-1, A velocity-1, and highest concavity curvature, but not CCT, were selected as the most important explanatory variables. In conclusion, many CST parameters were not significantly related to CCT, but IOP usually was a significant predictor, suggesting that an adjustment should be made to improve their usefulness for clinical investigations. It was also suggested CST parameters were more influential for IOP-G than CCT and average corneal curvature.