Blunting of Colon Contractions in Diabetics with Gastroparesis Quantified by Wireless Motility Capsule Methods

Generalized gut transit abnormalities are observed in some diabetics with gastroparesis. Relations of gastric emptying abnormalities to colon contractile dysfunction are poorly characterized. We measured colon transit and contractility using wireless motility capsules (WMC) in 41 healthy subjects, 1...

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Bibliographic Details
Published in:PloS one 2015-10, Vol.10 (10), p.e0141183-e0141183
Main Authors: Coleski, Radoslav, Wilding, Gregory E, Semler, John R, Hasler, William L
Format: Article
Language:English
Subjects:
Abnormalities
Adult
Analysis
Body mass index
Capsule Endoscopy - methods
Care and treatment
Colon
Constipation
Contractility
Correlation
Demographic variables
Demographics
Diabetes
Diabetes mellitus
Diabetics
Diagnosis
Emptying
Female
Gastric emptying
Gastric motility
Gastroenterology
Gastrointestinal surgery
Gastrointestinal Transit - physiology
Gastroparesis
Gastroparesis - diagnosis
Health aspects
Humans
Insulin
Internal medicine
Irritable bowel syndrome
Male
Mathematical analysis
Methods
Middle Aged
Motility
Muscle Contraction - physiology
Quartiles
Rodents
Transit
Vomiting
Womens health
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Summary:Generalized gut transit abnormalities are observed in some diabetics with gastroparesis. Relations of gastric emptying abnormalities to colon contractile dysfunction are poorly characterized. We measured colon transit and contractility using wireless motility capsules (WMC) in 41 healthy subjects, 12 diabetics with gastroparesis (defined by gastric retention >5 hours), and 8 diabetics with normal gastric emptying (≤5 hours). Overall numbers of colon contractions >25 mmHg were calculated in all subjects and were correlated with gastric emptying times for diabetics with gastroparesis. Colon transit periods were divided into quartiles by time and contraction numbers were calculated for each quartile to estimate regional colon contractility. Colon transit in diabetics with gastroparesis was prolonged vs. healthy subjects (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0141183