Conditions for Waveblock Due to Anisotropy in a Model of Human Ventricular Tissue

Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alig...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0141832-e0141832
Main Authors: Kudryashova, Nina N, Kazbanov, Ivan V, Panfilov, Alexander V, Agladze, Konstantin I
Format: Article
Language:English
Subjects:
Action Potentials
Analysis
Anisotropy
Arrhythmia
Astronomy
Biology
Blockage
Cardiac arrhythmia
Care and treatment
Complications and side effects
Heart
Humans
Hyperkalemia
Hyperkalemia - physiopathology
Ischemia
Life sciences
Mathematical models
Models, Cardiovascular
Physics
Potassium Channels - metabolism
Propagation
Reentry
Theory
Ventricle
Ventricular Function
Vortices
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Summary:Waveblock formation is the main cause of reentry. We have performed a comprehensive numerical modeling study of block formation due to anisotropy in Ten Tusscher and Panfilov (2006) ionic model for human ventricular tissue. We have examined the border between different areas of myocardial fiber alignment and have shown that blockage can occur for a wave traveling from a transverse fiber area to a longitudinal one. Such blockage occurs for reasonable values of the anisotropy ratio (AR): from 2.4 to 6.2 with respect to propagation velocities. This critical AR decreases by the suppression of INa and ICa, slightly decreases by the suppression of IKr and IKs, and substantially increases by the suppression of IK1. Hyperkalemia affects the block formation in a complex, biphasic way. We provide examples of reentry formation due to the studied effects and have concluded that the suppression of IK1 should be the most effective way to prevent waveblock at the areas of abrupt change in anisotropy.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0141832