Deciphering Depressive Mood in Relapsing-Remitting and Progressive Multiple Sclerosis and Its Consequence on Quality of Life

Depressive mood and other emotional symptoms are common in multiple sclerosis (MS). The patient-reported outcome version of the "Echelle d'Humeur Dépressive" (EHD-PRO) aims to differentiate between two dimensions of depressive mood in people living with MS (PwMS). First, to compare EH...

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Published in:PloS one 2015-11, Vol.10 (11), p.e0142152-e0142152
Main Authors: Lamargue Hamel, Delphine, Deloire, Mathilde, Ruet, Aurélie, Charré-Morin, Julie, Saubusse, Aurore, Ouallet, Jean-Christophe, Brochet, Bruno
Format: Article
Language:English
Subjects:
Adult
Alzheimer's disease
Anxiety
Clinical medicine
Cognitive ability
Complications and side effects
Correlation analysis
Depression - complications
Depression - psychology
Emotions
Fatigue
Female
Health aspects
Humans
Male
Mental depression
Middle Aged
Mood
Mood disorders
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - psychology
Neurological complications
Principal components analysis
Quality of Life
Questionnaires
Risk factors
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cited_by cdi_FETCH-LOGICAL-c692t-3df01408f98ddff799e4c110b9cd8cebd5e136fbc5c144f4ce82aa5d6ad962a33
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creator Lamargue Hamel, Delphine
Deloire, Mathilde
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description Depressive mood and other emotional symptoms are common in multiple sclerosis (MS). The patient-reported outcome version of the "Echelle d'Humeur Dépressive" (EHD-PRO) aims to differentiate between two dimensions of depressive mood in people living with MS (PwMS). First, to compare EHD-PRO assessment and its two dimensions, lack of emotional control and emotional blunting, between a large sample of healthy controls (HCs) and two samples of PwMS, relapsing-remitting MS (RRMS) and primary progressive MS (PPMS); and second, to analyse the relationships between EHD-PRO scores with neurological disability, cognitive function, fatigue and health-related quality of life (HR-QOL). Regardless of their phenotype, PwMS had significantly higher EHD-PRO scores than HCs. EHD-PRO scores did not differ between the two MS groups. EHD-PRO scores did not correlate with disability and fatigue scores, disease duration or cognitive z scores. In RRMS, the lack of emotional control was independently associated with a decrease in HR-QOL. The EHD-PRO is able to easily detect depressive mood and to differentiate between two clinical dimensions, emotional blunting and lack of emotional control. The scale is sensitive and seems robust to confounding factors. Lack of emotional control seems to contribute significantly to altered HR-QOL in RRMS.
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subjects Adult
Alzheimer's disease
Anxiety
Clinical medicine
Cognitive ability
Complications and side effects
Correlation analysis
Depression - complications
Depression - psychology
Emotions
Fatigue
Female
Health aspects
Humans
Male
Mental depression
Middle Aged
Mood
Mood disorders
Multiple sclerosis
Multiple Sclerosis, Relapsing-Remitting - complications
Multiple Sclerosis, Relapsing-Remitting - psychology
Neurological complications
Principal components analysis
Quality of Life
Questionnaires
Risk factors
title Deciphering Depressive Mood in Relapsing-Remitting and Progressive Multiple Sclerosis and Its Consequence on Quality of Life
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