Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stim...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0142902-e0142902
Main Authors: Yaluri, Nagendra, Modi, Shalem, López Rodríguez, Maykel, Stančáková, Alena, Kuusisto, Johanna, Kokkola, Tarja, Laakso, Markku
Format: Article
Language:English
Subjects:
Acetylcholine receptors (muscarinic)
Adenosine Triphosphate - chemistry
Animals
Calcium
Calcium (reticular)
Calcium - metabolism
Calcium channels
Calcium channels (voltage-gated)
Cardiovascular diseases
Cell Line
Channels
Colforsin - metabolism
Complications and side effects
Cyclic AMP - metabolism
Diabetes mellitus
Diabetes Mellitus - metabolism
Diabetes research
Disease susceptibility
Endoplasmic reticulum
Erythrocyte Membrane - metabolism
Fatty Acids - metabolism
Forskolin
Glucagon-Like Peptide-1 Receptor - metabolism
Glucose
Glucose - metabolism
Health aspects
Health risks
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Hypercholesterolemia
Hyperglycemia
Insulin
Insulin - metabolism
Insulin Secretion
Kinases
Male
Metabolic Syndrome - blood
Mice
Middle Aged
Molecular modelling
Pancreas
Pancreas - drug effects
Potassium
Potassium channels
Potassium channels (voltage-gated)
Pravastatin
Pravastatin - pharmacology
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - metabolism
Risk Factors
Rodents
Secretion
Signal Transduction
Simvastatin
Simvastatin - adverse effects
Simvastatin - pharmacology
Statins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current study, we show that simvastatin decreased glucose-stimulated insulin secretion in mouse pancreatic MIN6 β-cells by 59% and 79% (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0142902