A Gut Odyssey: The Impact of the Microbiota on Clostridium difficile Spore Formation and Germination

  Giel et al. later showed that small intestinal extracts from mice induce C. difficile spore germination [16].\n difficile spores, spores re-appear in the gut 24 hpi [12]. Since spore germination and outgrowth occur within 6 hpi, and spore formation takes approximately nine hours to complete in vit...

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Bibliographic Details
Published in:PLoS pathogens 2015-10, Vol.11 (10), p.e1005157-e1005157
Main Author: Shen, Aimee
Format: Article
Language:English
Subjects:
Animals
Antibiotics
Bacteriology
Bile
Charitable trusts
Clostridioides difficile - physiology
Gastrointestinal Microbiome
Genetic aspects
Germination
Humans
Infections
Metabolism
Microbiota (Symbiotic organisms)
Pearls
Spores, Bacterial
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Summary:  Giel et al. later showed that small intestinal extracts from mice induce C. difficile spore germination [16].\n difficile spores, spores re-appear in the gut 24 hpi [12]. Since spore germination and outgrowth occur within 6 hpi, and spore formation takes approximately nine hours to complete in vitro [26], these observations suggest that sporulation is induced ~15 hpi. Interestingly, a gut-adapted B. subtilis strain has a simplified pathway for regulating Spo0A, which allows it to induce sporulation more rapidly than the well-studied, lab-adapted strain [31]. Since the regulatory pathway of gut-adapted B. subtilis resembles C. difficile, and some intestinal symbionts divide exclusively using sporulation [28], gut-adapted organisms may use fewer checkpoints to initiate sporulation.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1005157