Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinati...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0143432-e0143432
Main Authors: Mellerup, Erling, Andreassen, Ole A, Bennike, Bente, Dam, Henrik, Djurovic, Srdjan, Hansen, Thomas, Jorgensen, Martin Balslev, Kessing, Lars Vedel, Koefoed, Pernille, Melle, Ingrid, Mors, Ole, Werge, Thomas, Moeller, Gert Lykke
Format: Article
Language:English
Subjects:
Analysis
Bipolar disorder
Bipolar Disorder - genetics
Breast cancer
Cardiovascular disease
Case-Control Studies
Cluster Analysis
Denmark
Gene polymorphism
Genes
Genetic aspects
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Genomes
Genomics
Genotype
Genotypes
Hospitals
Humans
Laboratories
Mental health
Models, Genetic
Models, Statistical
Neurosciences
Norway
Patients
Pharmacology
Physiological aspects
Polymorphism
Polymorphism, Single Nucleotide
Psychiatry
Risk Factors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
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Summary:The main objective of the study was to find combinations of genetic variants significantly associated with bipolar disorder. In a previous study of bipolar disorder, combinations of three single nucleotide polymorphism (SNP) genotypes taken from 803 SNPs were analyzed, and four clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of four SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from the new cluster and from the four previous clusters were identified in the genomes of 209 of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0143432