Candidate Gene Analysis of Mortality in Dialysis Patients

• Published in: PloS one 2015-11, Vol.10 (11), p.e0143079-e0143079
• Main Authors: Rothuizen, Tonia C, Ocak, Gurbey, Verschuren, Jeffrey J W, Dekker, Friedo W, Rabelink, Ton J, Jukema, J Wouter, Rotmans, Joris I
• Format: Article
• Language: English
• Subjects: Aged; Analysis; Calcium; Calcium metabolism; Calcium phosphates; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; Cardiovascular Diseases - pathology; Cell proliferation; Coagulation; Demographic aspects; Dialysis; Dialysis - adverse effects; Endothelium - metabolism; Endothelium - pathology; Epidemiology; Female; Genes; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Health risk assessment; Health risks; Hemodialysis patients; Humans; Inflammation - complications; Inflammation - genetics; Inflammation - pathology; Male; Metabolism; Middle Aged; Mortality; Netherlands; Patients; Phosphates; Physiological aspects; Polymorphism, Single Nucleotide; Renal Insufficiency, Chronic - complications; Renal Insufficiency, Chronic - genetics; Renal Insufficiency, Chronic - therapy; Single-nucleotide polymorphism; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - genetics; Vascular Remodeling - genetics
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0143079

Dialysis patients have high cardiovascular mortality risk. This study aimed to investigate the association between SNPs of genes involved in vascular processes and mortality in dialysis patients. Forty two SNPs in 25 genes involved in endothelial function, vascular remodeling, cell proliferation, inflammation, coagulation and calcium/phosphate metabolism were genotyped in 1330 incident dialysis patients. The effect of SNPs on 5-years cardiovascular and non-cardiovascular mortality was investigated. The mortality rate was 114/1000 person-years and 49.4% of total mortality was cardiovascular. After correction for multiple testing, VEGF rs699947 was associated with all-cause mortality (HR1.48, 95% CI 1.14-1.92). The other SNPs were not associated with mortality. This study provides further evidence that a SNP in the VEGF gene may contribute to the comorbid conditions of dialysis patients. Future studies should unravel the underlying mechanisms responsible for the increase in mortality in these patients.