Less Aggressive Surgical Procedure for Treatment of Solid Pseudopapillary Tumor: Limited Experience from a Single Institute

• Published in: PloS one 2015-11, Vol.10 (11), p.e0143452-e0143452
• Main Authors: Zhang, Chi, Liu, Fangfeng, Chang, Hong, Li, Hongguang, Zhou, Xu, Lu, Jun, Qin, Chengkun, Sun, Yongjie, Sun, Huidong, Lin, Jianbo
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Analysis; Carcinoma, Papillary - diagnostic imaging; Carcinoma, Papillary - surgery; Care and treatment; Child; Demography; Diagnosis; Dissection; Duodenum; Female; Females; Follow-Up Studies; Head & neck cancer; Health aspects; Hospitals; Humans; Liver; Lymph nodes; Male; Males; Medical diagnosis; Medical prognosis; Metastases; Metastasis; Middle Aged; Pancreas; Pancreatic cancer; Pancreatic Neoplasms - diagnostic imaging; Pancreatic Neoplasms - surgery; Pancreaticoduodenectomy; Patients; Preoperative Care; Preservation; Radiography, Abdominal; Risk factors; Signs and symptoms; Spleen; Splenectomy; Surgery; Surgical outcomes; Survival Analysis; Treatment Outcome; Tumors; Veins & arteries; Women; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0143452

To evaluate the clinical characteristics and radiological features of solid pseudopapillary tumor (SPT) and assess surgical therapy strategy. A retrospective review was performed in 62 patients pathologically confirmed of SPT treated between 2003 and 2014. The clinical features, radiological examinations and surgical strategies were analyzed. 56 females and 6 males were included in this study, mean age was 26 years old (range: 8-66 years old) with mean size of the tumor was 7.2 cm (range: 3-15 cm), and most tumor were commonly located in the head of pancreas (n = 29). Among all the cases, 3 patients had liver metastasis and underwent resection of SPT and liver metastasis. Furthermore, we performed 29 cases of local tumor excision; other patients underwent pancreaticoduodenectomy, middle pancreatectomy, middle pancreatectomy with splenectomy, distal pancreatectomy with spleen preservation, distal pancreatectomy with splenectomy and duodenum-preserving pancreatic head resection. No patient suffered from lymph node metastases. After median follow-up of 46 months (range: 2-135 months), no mortality or local recurrence or distant metastasis was found. Solid pseudopapillary tumor is a latent malignant tumor with excellent prognosis. If feasible, less aggressive resection without regular lymphadenectomy is recommended for treatment of patients with SPT.