Double-Layer Magnetic Nanoparticle-Embedded Silica Particles for Efficient Bio-Separation

Superparamagnetic Fe3O4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe3O4 NPs by magnets may limit broad applications of Fe3O4 NP-based nanomaterials. In this study, we report fabrication...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0143727
Main Authors: Kyeong, San, Jeong, Cheolhwan, Kang, Homan, Cho, Hong-Jun, Park, Sung-Jun, Yang, Jin-Kyoung, Kim, Sehoon, Kim, Hyung-Mo, Jun, Bong-Hyun, Lee, Yoon-Sik
Format: Article
Language:English
Subjects:
Accumulation
Bioengineering
Biomolecules
Biotechnology
Chemicals
Chemistry
Dopamine
Engineering
Fabrication
Ferrosoferric Oxide - chemistry
Iron oxides
Kinetics
Ligands
Magnetic fields
Magnetic properties
Magnetite Nanoparticles - chemistry
Magnets
Nanomaterials
Nanoparticles
Nanotechnology
Nanotechnology - methods
Quantum dots
Science
Separation
Silica
Silicon dioxide
Silicon Dioxide - chemistry
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Summary:Superparamagnetic Fe3O4 nanoparticles (NPs) based nanomaterials have been exploited in various biotechnology fields including biomolecule separation. However, slow accumulation of Fe3O4 NPs by magnets may limit broad applications of Fe3O4 NP-based nanomaterials. In this study, we report fabrication of Fe3O4 NPs double-layered silica nanoparticles (DL MNPs) with a silica core and highly packed Fe3O4 NPs layers. The DL MNPs had a superparamagnetic property and efficient accumulation kinetics under an external magnetic field. Moreover, the magnetic field-exposed DL MNPs show quantitative accumulation, whereas Fe3O4 NPs single-layered silica nanoparticles (SL MNPs) and silica-coated Fe3O4 NPs produced a saturated plateau under full recovery of the NPs. DL MNPs are promising nanomaterials with great potential to separate and analyze biomolecules.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0143727