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Associations between Medical Conditions and Breast Cancer Risk in Asians: A Nationwide Population-Based Study in Taiwan

The breast cancer incidence in Asia is rising. To explore whether the etiology of breast cancer is different from the known risk factors from studies in Western countries, we conducted a nested case-control study using data from the Taiwan National Health Insurance Research Database (NHIRD). All med...

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Bibliographic Details
Published in:PloS one 2015-11, Vol.10 (11), p.e0143410-e0143410
Main Authors: Chuang, Shu-Chun, Wu, Guo-Jie, Lu, Yen-Shen, Lin, Ching-Hung, Hsiung, Chao Agnes
Format: Article
Language:English
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Summary:The breast cancer incidence in Asia is rising. To explore whether the etiology of breast cancer is different from the known risk factors from studies in Western countries, we conducted a nested case-control study using data from the Taiwan National Health Insurance Research Database (NHIRD). All medical conditions based on the first three digits of the ICD-9 and a list of medical conditions based on literature review were retrieved for each case and control. The odds ratios (OR) and 95% confidence intervals (CI) of the associations between medical conditions and breast cancer risks were estimated using conditional logistic regression and adjusted for occupation, number of breast cancer screening, and the average number of outpatient visits prior the diagnosis. The associations were also estimated for younger (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0143410