Improvement in Human Immune Function with Changes in Intestinal Microbiota by Salacia reticulata Extract Ingestion: A Randomized Placebo-Controlled Trial

Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cell...

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Bibliographic Details
Published in:PloS one 2015-12, Vol.10 (12), p.e0142909-e0142909
Main Authors: Oda, Yuriko, Ueda, Fumitaka, Utsuyama, Masanori, Kamei, Asuka, Kakinuma, Chihaya, Abe, Keiko, Hirokawa, Katsuiku
Format: Article
Language:English
Subjects:
Age
Animals
Bacteria
Biomarkers - metabolism
Blood
Blood cells
Cell proliferation
Clinical trials
Dendritic cells
Double-Blind Method
Eating
Epithelial cells
Gastrointestinal Microbiome - drug effects
Gene expression
Gene Expression Profiling
Genes
High-Throughput Nucleotide Sequencing - methods
Humans
Immune response
Immune system
Immunology
Ingestion
Intestinal microflora
Intestinal Mucosa - drug effects
Intestinal Mucosa - immunology
Intestinal Mucosa - metabolism
Intestinal Mucosa - microbiology
Intestine
Laboratories
Life sciences
Lymphocytes T
Male
Medical research
Methods
Microbiota
Microbiota (Symbiotic organisms)
Middle Aged
Older people
Pharmaceuticals
Plant Extracts - pharmacology
Polyphenols
Prebiotics
R&D
Rats
Research & development
Rodents
Salacia
Salacia - chemistry
Sugar
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Summary:Plants belonging to the genus Salacia in the Hippocrateaceae family are known to inhibit sugar absorption. In a previous study, administration of Salacia reticulata extract in rats altered the intestinal microbiota and increased expression of immune-relevant genes in small intestinal epithelial cells. This study aimed to investigate the effect of S. reticulata extract in human subjects by examining the gene expression profiles of blood cells, immunological indices, and intestinal microbiota. The results revealed an improvement in T-cell proliferation activity and some other immunological indices. In addition, the intestinal microbiota changed, with an increase in Bifidobacterium and a decrease in Clostridium bacteria. The expression levels of many immune-relevant genes were altered in blood cells. We concluded that S. reticulata extract ingestion in humans improved immune functions and changed the intestinal microbiota. UMIN Clinical Trials Registry UMIN000011732.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0142909