Center-Related Determinants of VKA Anticoagulation Quality: A Prospective, Multicenter Evaluation

Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood. We aimed at evaluating wh...

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Bibliographic Details
Published in:PloS one 2015-12, Vol.10 (12), p.e0144314-e0144314
Main Authors: Tosetto, Alberto, Manotti, Cesare, Marongiu, Francesco
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis
Anticoagulants
Anticoagulants - administration & dosage
Anticoagulants - pharmacokinetics
Cardiac arrhythmia
Dosage and administration
Drug dosages
Drug Monitoring
Evaluation
Female
Humans
International Normalized Ratio
Male
Medical research
Medicine
Meta-analysis
Patients
Prospective Studies
Quality
Quality of Health Care
Regression analysis
Regression models
Systematic review
Thromboembolism
Thrombosis
Variables
Vitamin K
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Summary:Center-specific TTR (c-TTR) is a measure reporting the mean patient TTR within an anticoagulation clinic describing the quality of anticoagulant monitoring offered by that clinic. c-TTR has a considerable between-center variation, but its determinants are poorly understood. We aimed at evaluating which clinical, procedural or laboratory factors could be associated with c-TTR variability in a multicenter, observational cross-sectional study over a five-year period. Data from 832,204 individual patients followed for VKA therapy in 292 Centers affiliated with the Italian Federation of Anticoagulation Clinics (FCSA) were analyzed. c-TTR was computed based on the TTR of patients followed at each Center, and a mixed linear regression model was used for a predefined set of explanatory variables. The Center next-visit interval ratio (the mean number of days after a visit with an INR outside the therapeutic range, divided by the days after a visit with an INR within the therapeutic range), the Center mean patient INR and the Center laboratory performance at EQA proficiency testing were the only variables that were independently associated with c-TTR (β-coefficients -17.32, 9.67, and -0.11, respectively; r2 = 0.635). These findings suggest that c-TTR associates with proactive strategies aimed at keeping patients very close to their target INR with a prompt re-evaluation of those patients with under- or over-therapeutic INR.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0144314