A Single Arm Pilot Study of Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome

To evaluate the effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome. Berberine 0.4 g three times per day was given for four months to 102 anovulatory Chinese women with polycystic ovary syndrome. T...

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Published in:PloS one 2015-12, Vol.10 (12), p.e0144072-e0144072
Main Authors: Li, Lin, Li, Chengyan, Pan, Ping, Chen, Xiaoli, Wu, Xiaoke, Ng, Ernest Hung Yu, Yang, Dongzi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anovulation
Berberine
Berberine - pharmacology
Binding
Birth rate
Body mass index
Body weight
Care and treatment
China
Chinese medicine
Cholesterol
Complications and side effects
Diabetes
Female
Globulins
Gonadal Steroid Hormones - metabolism
Gynecology
Humans
In vitro fertilization
Infertility
Influence
Insulin
Insulin resistance
Menstruation
Menstruation - drug effects
Metabolism
Obstetrics
Overweight
Ovulation
Ovulation - drug effects
Pilot Projects
Polycystic ovary syndrome
Polycystic Ovary Syndrome - metabolism
Polycystic Ovary Syndrome - physiopathology
Pregnancy
Progesterone
Prospective Studies
Sex
Sex hormones
Triglycerides
Ultrasonic imaging
Young Adult
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cited_by cdi_FETCH-LOGICAL-c692t-a9a2bb14c3e78b53f93a6a72c89d6898cf152ced331338f58e0e660f4c873b493
cites cdi_FETCH-LOGICAL-c692t-a9a2bb14c3e78b53f93a6a72c89d6898cf152ced331338f58e0e660f4c873b493
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container_issue 12
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creator Li, Lin
Li, Chengyan
Pan, Ping
Chen, Xiaoli
Wu, Xiaoke
Ng, Ernest Hung Yu
Yang, Dongzi
description To evaluate the effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome. Berberine 0.4 g three times per day was given for four months to 102 anovulatory Chinese women with polycystic ovary syndrome. The menstrual pattern, ovulation rate, hormonal and metabolic profiles were compared before and after the berberine treatment. Ovulation was confirmed by serum progesterone level ≥10 ng/ml. A total of 98 of 102 subjects (96.1%) completed the four month treatment, including 69 (70.4%, 69/98) normal weight and 29 (29.6%, 29/98) overweight/obese. Fourteen women (14.3%, 14/98) had regained regular menses after berberine treatment and there was no significant difference between normal weight and overweight/obese groups. The ovulation rate was 25.0% over four months in the whole group, 22.5% in the normal weight group and 31.0% in the overweight/obese group. Sex hormone binding globulin, insulin resistance, total cholesterol, total triglyceride and low-density lipoprotein cholesterol decreased after berberine treatment in the normal weight group only. Our study found that administration of berberine alone may improve the menstrual pattern and ovulation rate in anovulatory Chinese women with polycystic ovary syndrome. Berberine can also decrease sex hormone binding globulin, insulin resistance, total cholesterol, triglycerides and low-density lipoprotein cholesterol in normal weight polycystic ovary syndrome women. Chictr.org ChiCTR-OO-13003943.
doi_str_mv 10.1371/journal.pone.0144072
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A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Single Arm Pilot Study of Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-12-08</date><risdate>2015</risdate><volume>10</volume><issue>12</issue><spage>e0144072</spage><epage>e0144072</epage><pages>e0144072-e0144072</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the effects of berberine on the menstrual pattern, ovulation rate, hormonal and metabolic profiles in anovulatory Chinese women with polycystic ovary syndrome. Berberine 0.4 g three times per day was given for four months to 102 anovulatory Chinese women with polycystic ovary syndrome. The menstrual pattern, ovulation rate, hormonal and metabolic profiles were compared before and after the berberine treatment. Ovulation was confirmed by serum progesterone level ≥10 ng/ml. A total of 98 of 102 subjects (96.1%) completed the four month treatment, including 69 (70.4%, 69/98) normal weight and 29 (29.6%, 29/98) overweight/obese. Fourteen women (14.3%, 14/98) had regained regular menses after berberine treatment and there was no significant difference between normal weight and overweight/obese groups. The ovulation rate was 25.0% over four months in the whole group, 22.5% in the normal weight group and 31.0% in the overweight/obese group. Sex hormone binding globulin, insulin resistance, total cholesterol, total triglyceride and low-density lipoprotein cholesterol decreased after berberine treatment in the normal weight group only. Our study found that administration of berberine alone may improve the menstrual pattern and ovulation rate in anovulatory Chinese women with polycystic ovary syndrome. Berberine can also decrease sex hormone binding globulin, insulin resistance, total cholesterol, triglycerides and low-density lipoprotein cholesterol in normal weight polycystic ovary syndrome women. Chictr.org ChiCTR-OO-13003943.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26645811</pmid><doi>10.1371/journal.pone.0144072</doi><oa>free_for_read</oa></addata></record>
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source Publicly Available Content Database; PubMed Central
subjects Adolescent
Adult
Anovulation
Berberine
Berberine - pharmacology
Binding
Birth rate
Body mass index
Body weight
Care and treatment
China
Chinese medicine
Cholesterol
Complications and side effects
Diabetes
Female
Globulins
Gonadal Steroid Hormones - metabolism
Gynecology
Humans
In vitro fertilization
Infertility
Influence
Insulin
Insulin resistance
Menstruation
Menstruation - drug effects
Metabolism
Obstetrics
Overweight
Ovulation
Ovulation - drug effects
Pilot Projects
Polycystic ovary syndrome
Polycystic Ovary Syndrome - metabolism
Polycystic Ovary Syndrome - physiopathology
Pregnancy
Progesterone
Prospective Studies
Sex
Sex hormones
Triglycerides
Ultrasonic imaging
Young Adult
title A Single Arm Pilot Study of Effects of Berberine on the Menstrual Pattern, Ovulation Rate, Hormonal and Metabolic Profiles in Anovulatory Chinese Women with Polycystic Ovary Syndrome
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